师资队伍

师资队伍

研究组成员

郑丽霞

副研究员

  • 邮箱:1090236329@qq.com

  • 地址:前湖校区南院科创楼301

  • 研究方向:心肌细胞增殖调控与心脏再生研究

个人简介

郑丽霞博士,2017年本科毕业于哈尔滨医科大学,2022年博士毕业于北京大学,2022-2025年在北京大学未来技术学院从事博士后研究工作。以第一作者含共同Cell Stem Cell、Journal of Molecular Cell Biology、STAR Protocols、Cell Regeneration等期刊发表论文5篇。以共同作者在Nature Communications、eLife、Disease Models & Mechanisms等期刊发表论文5篇;作为共同发明人获得授权发明专利9项。现主持国家自然科学基金青年科学基金1项。


研究方向

1)基于化学小分子组合的心肌细胞增殖调控与心脏再生研究;

2)结合多组学技术解析心脏再生过程中的细胞与分子机制。


近五年代表性论文

1.Du J#, Zheng L#, Gao P, Yang H, Yang WJ, Guo F, Liang R, Feng M, Wang Z, Zhang Z, Bai L, Bu Y, Xing S, Zheng W, Wang X, Quan L, Hu X, Wu H, Chen Z, Chen L, Wei K, Zhang Z, Zhu X, Zhang X, Tu Q, Zhao SM*, Lei X*, Xiong JW*. A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. Cell Stem Cell. 2022; 29(4):545-558.e13.

2.Zheng L#, Chen Y#, Xiong JW*. Rewiring cell identity and metabolism to drive cardiomyocyte proliferation. Cell Regen. 2025; 14(1):40.

3.Zheng L#, Chen Y#, Wu Z, Zhu X, Xiong JW*. Effective therapy of the small-molecule cocktail 5SM on adult rat heart after ischemia-reperfusion injury. J Mol Cell Biol. 2023; 15(6):mjad034.

4.Zheng L#, Wang Z#, Du J#, Zhu X, Xiong JW*. Protocol to identify small molecules promoting rat and mouse cardiomyocyte proliferation based on the FUCCI and MADM reporters. STAR Protoc. 2022; 3(4):101903.

5.Zheng L#, Du J#, Wang Z, Zhou Q, Zhu X, Xiong JW*. Molecular regulation of myocardial proliferation and regeneration. Cell Regen. 2021; 10(1):13.

Zhang Z#, Zheng L, Chen Y, Chen Y, Hou J, Xiao C, Zhu X, Zhao SM, Xiong JW*.

6. AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism. Elife. 2025; 13:RP99670.

7.Chen Y#, Du J, Zheng L, Wang Z, Zhang Z, Wu Z, Zhu X, Xiong JW*. Chemical screening links disulfiram with cardiac protection after ischemic injury. Cell Regen. 2023; 12(1):25.

8.Zhang Z#, Chen Y, Zheng L, Du J, Wei S, Zhu X, Xiong JW*. A DUSP6 inhibitor suppresses inflammatory cardiac remodeling and improves heart function after myocardial infarction. Dis Model Mech. 2023; 16(5):dmm049662.

9.Zhou X#, Zhang C#, Wu X#, Hu X, Zhang Y, Wang X, Zheng L, Gao P, Du J, Zheng W, Shang H, Hu K, Jiang Z, Nie Y, Hu S, Xiao RP, Zhu X, Xiong JW*. Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction. Nat Commun. 2022; 13(1):6672.

10.Pang M#, Xiong C, Xiao C, Du J, Zheng L, Bai L, Zhu X, Xiong JW*. Critical role of zebrafish dnajb5 in myocardial proliferation and regeneration. J Genet Genomics. 2020; 47(8):493-496.