NOW: HOME - FACULTY - Research Groups - Ansgar Poetsch Lab
E-mail：ansgarpoetsch@ncu.edu.cn
Address：Room 221, Medical Science and Technology Innovation Center
Educational Experience：
October 1990-September 1993 Technical University of Darmstadt Undergraduate
October 1993-September 1995 Technical University of Darmstadt Master's Degree Candidate
October 1995-May 1999 Technical University of Darmstadt Doctoral Candidate
Work Experience:
August 1999 – May 2001 University of British Columbia, Canada
July 2001 – September 2002 University of Ulm, Germany
October 2002 – January 2017 Department of Biology, Ruhr University Bochum, Germany
January 2017 – June 2019 Faculty of Medicine, University of Plymouth, UK
July 2019–March 2022 Public Technology Platform of Marine Molecular Biotechnology, National Laboratory for Marine Science and Technology (Qingdao), China
April 2022 – Present Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University
Academic Appointments:
Member of the German Society for Applied Microbiology (VAAM) and the German Society for Proteomics (HUPO), Editor and Reviewer for Biology, Guest Editor for Frontiers in Microbiology, Editor for Frontiers in Molecular Biosciences, and Ad Hoc Reviewer for prestigious journals including Nature Protocols, Proteomics, and the Journal of Proteome Research. Additionally, serving as a Grant Reviewer for funding agencies such as the DFG, BBSRC, and the EU.
Awards and Honors:
2000 Feodor-Lynen Research Fellowship, Alexander von Humboldt Foundation
2004 Young Scientist Award, Human Proteome Organization (HUPO)
2009 Excellent Young Research Team Award, German Federal Ministry of Education and Research (BMBF)
2015 President’s Award, Chinese Academy of Sciences (CAS)
2018 International Academic Award, Higher Education Academy (HEA), UK
2022 High-level Talent (Category C), Jiangxi Province, China
1. Posttranslational modifications in aging and age-related diseases: Investigating the regulatory mechanisms of senescent extracellular vesicles using proteomics and cell biology;
2. Elucidation of sperm membrane protein function: Identifying unknown membrane proteins in sperm and testis using proteomics, analyzing the functions of candidate unknown proteins in testis using mouse models, and exploring the roles of post-translational modifications in sperm;
3. Development of mass spectrometry-based methods for the Identification of Biomarkers for Major Diseases: Fractionation and enrichment methods for liquid biopsy and application to characterize human samples and animal disease models
1. Chen, X.; Poetsch, A. , The Role of Cdo1 in Ferroptosis and Apoptosis in Cancer. Biomedicines, 2024, 12, 918.
2. Jian, H.; Poetsch, A. , CASZ1: Current Implications in Cardiovascular Diseases and Cancers. Biomedicines, 2023, 11, 2079.
3. Schmidt, A., Frei, J., Poetsch, A. , et al., MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation. Front Cell Dev Biol, 2022, 10: p. 941493.
4. Luenenschloss, A., Veld, F., Albaum, S., Neddermann, T., Wendisch, V., Poetsch, A., et al.,Functional Genomics Uncovers Pleiotropic Role of Rhomboids in Corynebacterium glutamicum. Frontiers in Microbiology, 2022. 13.
5. Marchesini MI, Poetsch A., Guidolin L.S., Comerci D.J. Brucella abortus Encodes an Active Rhomboid Protease: Proteome Response after Rhomboid Gene Deletion. Microorganisms, 2022;10(1).
6. Trötschel, C., Hamzeh, H., Alvarez, L., Pascal, R., Lavryk, F., Poetsch,A., et al., Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation. Embo j, 2020. 39(4): p. e102723.
7. Chaoyun，Chen., Harst, W., Wuxin Y., Poetsch, A., et al., Proteomic study uncovers molecular principles of single-cell-level phenotypic heterogeneity in lipid storage of Nannochloropsis oceanica. Biotechnol Biofuels, 2019. 12: p. 21.
8. Ogorodnikov, A., Poetsch, A., et al., Transcriptome 3′end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma. Nature Communications, 2018. 9(1): p. 5331.
9. Guevara, C.R.;Philipp, O.;Hamann, A.;Werner, A.;Osiewacz, H.D.;Rexroth, S.;Rögner, M., Poetsch, A., et al., Global Protein Oxidation Profiling Suggests Efficient Mitochondrial Proteome Homeostasis During Aging. Mol Cell Proteomics, 2016. 15(5): p. 1692-709.
10. Cerletti, M., Paggi, R.A., Guevara, C.R., Poetsch, A., et al., Global role of the membrane protease LonB in Archaea: Potential protease targets revealed by quantitative proteome analysis of a lonB mutant in Haloferax volcanii. J Proteomics, 2015. 121: p. 1-14.
11. Vera, M., Krok, B., Bellenberg, S., Sand. W., Poetsch, A., Shotgun proteomics study of early biofilm formation process of Acidithiobacillus ferrooxidans ATCC 23270 on pyrite. Proteomics, 2013. 13(7): p. 1133-44.
12. Trotschel, C., et al., Protein turnover quantification in a multilabeling approach: from data calculation to evaluation. Mol Cell Proteomics, 2012. 11(8): p. 512-26.
13. Rietschel, B., Tabiwang, N., Arrey, B., Meyer1, A., Bornemann1, S., Schuerken1, M., Poetsch, A., et al., Elastase digests: new ammunition for shotgun membrane proteomics. Mol Cell Proteomics, 2009. 8(5): p. 1029-43.
14. Gertz, M., Seelert, H., Dencher, N., Poetsch, A., et al., Interactions of rotor subunits in the chloroplast ATP synthase modulated by nucleotides and by Mg2+. Biochim Biophys Acta, 2007. 1774(5): p. 566-74.
15. Fischer, F., Wolters, D., Rögner, M., Poetsch, A., et al., Toward the complete membrane proteome - High coverage of integral membrane proteins through transmembrane peptide detection. Molecular & Cellular Proteomics, 2006. 5(3): p. 444-453.
16. Poetsch, A., L. Molday, and R. Molday, The cGMP-gated channel and related glutamic acid-rich proteins interact with peripherin-2 at the rim region of rod photoreceptor disc membranes. Journal of Biological Chemistry, 2001. 276(51): p. 48009-48016.
17. Seelert, H., Poetsch, A., et al., Structural biology - Proton-powered turbine of a plant motor. Nature, 2000. 405(6785): p. 418-419
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