NOW: HOME - FACULTY - Research Groups - Ansgar Poetsch Lab
E-mail：ansgarpoetsch@ncu.edu.cn
Address：Room 221, Medical Science and Technology Innovation Center
Professor Ansgar Poetsch obtained his PhD in Biophysical Chemistry from the Technical University of Darmstadt, Germany, in 1999. From 2002 to 2019, he served as an Associate Professor at Ruhr-Universität Bochum (Germany) and the University of Plymouth (UK) successively. He has presided over 17 research projects funded by foundations in Germany, Spain, China, and other countries. He has published 102 papers in SCI-indexed journals such as Nature, Nat. Communications, and EMBO Journal, including 42 papers as the first author or corresponding author. He has also participated in compiling 6 monographs and been granted 2 patents in Europe.
Professor Poetsch has received numerous awards and honors, including the President’s Award of the Chinese Academy of Sciences, the Young Scientist Award from the Human Proteome Organization (HUPO) for Natural Sciences, the Award of the Higher Education Academy (UK), and the Young Research Team Award from the German Federal Ministry of Education and Research. He was selected for the 4th Batch of the Foreign Experts Recruitment Program (for introduced foreign experts).
He holds various academic positions, including memberships in the German Society for Applied Microbiology and the German Human Proteome Organization (HUPO). He serves as an Editor and Reviewer for Biology, a Guest Editor for Frontiers in Microbiology, and an Ad Hoc Reviewer for academic journals such as Nature Protocols, Proteomics, and Journal of Proteome Research. Additionally, he acts as a Reviewer for funding bodies including the German Research Foundation (DFG), the Biotechnology and Biological Sciences Research Council (BBSRC), and the European Union (EU).
1. Posttranslational modifications in aging and age-related diseases: Investigating the regulatory mechanisms of senescent extracellular vesicles using proteomics and cell biology;
2. Elucidation of sperm membrane protein function: Identifying unknown membrane proteins in sperm and testis using proteomics, analyzing the functions of candidate unknown proteins in testis using mouse models, and exploring the roles of post-translational modifications in sperm;
3. Development of mass spectrometry-based methods for the Identification of Biomarkers for Major Diseases: Fractionation and enrichment methods for liquid biopsy and application to characterize human samples and animal disease models
1. Chen, X.; Poetsch, A. , The Role of Cdo1 in Ferroptosis and Apoptosis in Cancer. Biomedicines, 2024, 12, 918.
2. Jian, H.; Poetsch, A. , CASZ1: Current Implications in Cardiovascular Diseases and Cancers. Biomedicines, 2023, 11, 2079.
3. Schmidt, A., Frei, J., Poetsch, A. , et al., MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation. Front Cell Dev Biol, 2022, 10: p. 941493.
4. Luenenschloss, A., Veld, F., Albaum, S., Neddermann, T., Wendisch, V., Poetsch, A., et al.,Functional Genomics Uncovers Pleiotropic Role of Rhomboids in Corynebacterium glutamicum. Frontiers in Microbiology, 2022. 13.
5. Marchesini MI, Poetsch A., Guidolin L.S., Comerci D.J. Brucella abortus Encodes an Active Rhomboid Protease: Proteome Response after Rhomboid Gene Deletion. Microorganisms, 2022;10(1).
6. Trötschel, C., Hamzeh, H., Alvarez, L., Pascal, R., Lavryk, F., Poetsch,A., et al., Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation. Embo j, 2020. 39(4): p. e102723.
7. Chaoyun，Chen., Harst, W., Wuxin Y., Poetsch, A., et al., Proteomic study uncovers molecular principles of single-cell-level phenotypic heterogeneity in lipid storage of Nannochloropsis oceanica. Biotechnol Biofuels, 2019. 12: p. 21.
8. Ogorodnikov, A., Poetsch, A., et al., Transcriptome 3′end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma. Nature Communications, 2018. 9(1): p. 5331.
9. Guevara, C.R.;Philipp, O.;Hamann, A.;Werner, A.;Osiewacz, H.D.;Rexroth, S.;Rögner, M., Poetsch, A., et al., Global Protein Oxidation Profiling Suggests Efficient Mitochondrial Proteome Homeostasis During Aging. Mol Cell Proteomics, 2016. 15(5): p. 1692-709.
10. Cerletti, M., Paggi, R.A., Guevara, C.R., Poetsch, A., et al., Global role of the membrane protease LonB in Archaea: Potential protease targets revealed by quantitative proteome analysis of a lonB mutant in Haloferax volcanii. J Proteomics, 2015. 121: p. 1-14.
11. Vera, M., Krok, B., Bellenberg, S., Sand. W., Poetsch, A., Shotgun proteomics study of early biofilm formation process of Acidithiobacillus ferrooxidans ATCC 23270 on pyrite. Proteomics, 2013. 13(7): p. 1133-44.
12. Trotschel, C., et al., Protein turnover quantification in a multilabeling approach: from data calculation to evaluation. Mol Cell Proteomics, 2012. 11(8): p. 512-26.
13. Rietschel, B., Tabiwang, N., Arrey, B., Meyer1, A., Bornemann1, S., Schuerken1, M., Poetsch, A., et al., Elastase digests: new ammunition for shotgun membrane proteomics. Mol Cell Proteomics, 2009. 8(5): p. 1029-43.
14. Gertz, M., Seelert, H., Dencher, N., Poetsch, A., et al., Interactions of rotor subunits in the chloroplast ATP synthase modulated by nucleotides and by Mg2+. Biochim Biophys Acta, 2007. 1774(5): p. 566-74.
15. Fischer, F., Wolters, D., Rögner, M., Poetsch, A., et al., Toward the complete membrane proteome - High coverage of integral membrane proteins through transmembrane peptide detection. Molecular & Cellular Proteomics, 2006. 5(3): p. 444-453.
16. Poetsch, A., L. Molday, and R. Molday, The cGMP-gated channel and related glutamic acid-rich proteins interact with peripherin-2 at the rim region of rod photoreceptor disc membranes. Journal of Biological Chemistry, 2001. 276(51): p. 48009-48016.
17. Seelert, H., Poetsch, A., et al., Structural biology - Proton-powered turbine of a plant motor. Nature, 2000. 405(6785): p. 418-419
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