Educational Background

2019-2023, Southern University of Science and Technology (SUSTech), School of Medicine, Doctoral Degree;

2014-2017, Wuhan University, School of Basic Medical Sciences, Master's Degree;

2009-2013, Huangshan University, School of Chemistry and Chemical Engineering, Bachelor's Degree.

Work Experience

2026.02 - Present, Institute of Biomedical Innovation/College of Pharmacy, Nanchang University, PI/Ph.D. Supervisor

2023.07 - 2025.09, SUSTech, Postdoctoral Researcher

2025.10 - 2025.12, SUSTech, Senior Research Scholar

Academic Appointments

Member of Division of anesthetic pharmacology，Chinese Pharmacological Society，CPAP

Awards and Honors

Chang Hsiang-Tung Neuroscience Outstanding Graduate Student Paper Award 2025

Our laboratory investigates the neurobiological mechanisms underlying consciousness-state regulation, with a sustained focus on the reversible neural transitions that define general anesthesia—specifically, the dynamic processes of induction, maintenance, and emergence. Challenging the long-standing assumption that post-anesthetic recovery is merely a passive consequence of drug clearance, we pioneered the “active recovery hypothesis” and identified thalamic KCC2 ubiquitin-mediated degradation as a causal molecular switch for anesthesia emergence—a discovery representing the first mechanistic link between targeted ion transporter regulation and conscious state restoration. Building on this foundation, we seek to establish a unified, circuit-level framework for how cortico-subcortical networks orchestrate consciousness transitions through temporally precise molecular adaptations and activity-dependent functional reorganization across the full anesthesia cycle. Our work aims to redefine consciousness-state control as an endogenous, biologically regulated process—and to translate these insights into next-generation strategies for precision anesthesia and targeted arousal enhancement.

We integrate state-of-the-art approaches spanning systems neuroscience, molecular pharmacology, and computational biology, including: monosynaptic viral tracing; cell-type-specific opto- and chemogenetic modulation; in vivo pharmacological perturbation; multi-region fiber photometry with genetically encoded sensors; two-photon calcium imaging in awake, behaving mice; chronic in vivo electrophysiology (tetrode and Neuropixel recordings); ex vivo brain-slice patch-clamp and synaptic physiology; CRISPR-based molecular interventions; bulk and single-cell multi-omics profiling (transcriptomics, proteomics, epigenomics); quantitative immunohistochemistry with spatial transcriptomic correlation; and biophysically constrained computational modeling of thalamocortical dynamics.

Every project in our lab begins not with a technique, but with a carefully observed anomaly—an unexpected deviation in neural dynamics, behavioral output, or molecular signature. From such observations, we rigorously formulate testable hypotheses, then deploy the most appropriate combination of experimental and analytical tools to uncover underlying biological principles.