NOW: HOME - FACULTY - Research Groups - XIAO Jian Lab
E-mail：xiaojian5278@ncu.edu.cn
Address：Room 307, Medical Science and Technology Innovation Center
Xiao Jian，Male | Born in Hengyang, Hunan Province. His research primarily focuses on cholesterol metabolism and inherited cardiomyopathies. He has published 6 papers as first author or co-first author in internationally renowned academic journals such as Nature Communications and Protein & Cell.
Education and Professional Experience
(1) Sep 2010 – Jun 2014
Bachelor of Science, College of Life Sciences, Wuhan University
(2) Sep 2014 – Dec 2019
Ph.D., College of Life Sciences, Wuhan University
(3) Jan 2020 – Dec 2023
Postdoctoral Researcher, College of Life Sciences, Wuhan University
(4) Jan 2024 – Present
Specially Appointed Researcher, School of Basic Medical Sciences / Institute of Biomedical Innovation, Nanchang University
Our research focuses on cholesterol metabolism and cardiometabolic diseases. Cholesterol, an essential lipid molecule, is closely linked to cardiovascular, neurodegenerative, and other diseases. Cholesterol metabolism-related proteins have long been key drug targets for many human diseases. To date, the team has contributed 6 first/co-first-author publications in peer-reviewed journals, with representative works in Nature Communications and Protein & Cell. Key achievements include:
(1) Discovering a novel intracellular cholesterol transport pathway, proposing membrane organelles as dynamic carriers—expanding understanding of cholesterol trafficking;
(2) Challenging the dogma that "all PCSK proteins self-catalyze maturation" by identifying POST1/C12orf49 as the first maturation facilitator for PCSKs family;
(3) Elucidating molecular mechanisms of intestinal cholesterol absorption, revealing key effectors and regulatory networks to inform dietary cholesterol intervention strategies.
(1) Jian Xiao, Yanni Xiong, Liu-Ting Yang, Ju-Qiong Wang, Zi-Mu Zhou, Le-Wei Dong, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo*, Bao-Liang Song*. POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation. Protein & Cell, 2021. 12(4): 279-296.
(2) Jian Xiao#, Le-Wei Dong#, Shuai Liu, Fan-Hua Meng, Chang Xie, Xiao-Yi Lu, Weiping J. Zhang, Jie Luo, Bao-Liang Song*. Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling. Nature Communications, 2023. 14(1):6469.
(3) Jian Xiao#, Jie Luo#, Ao Hu, Ting Xiao, Mei-Xin Li, Ze-Kai Kong, Lu-Yi Jiang, Zi-Mu Zhou, Ya-Cheng Liao, Chang Xie, Bei-Bei Chu, Hong-Hua Miao, Bo-Liang Li, Xiong-Jie Shi, Bao-Liang Song*. Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins. (Cover story). Science China-Life Sciences, 2019. 62(9):1117-1135.
(4) Le-Wei Dong#, Jian Xiao#, Ya-Cheng Liao, Bei-Bei Chu, Gang Deng, Xiao-Lu Zhao, Bao-Liang Song, Jie Luo*. Lysosomal cholesterol accumulation is commonly found in most peroxisomal disorders and reversed by 2-hydroxypropyl-β-cyclodextrin. Science China-Life Sciences, 2023. 66(8):1786-1799.
(5) Fan-Hua Meng#, Shuai Liu#, Jian Xiao#, Yu-Xia Zhou, Le-Wei Dong, Yun-Feng Li, Yan-Qing Zhang, Wei-Hui Li, Ju-Qiong Wang, Yan Wang, Bao-Liang Song, Yi-Tong M, Zhen-Yan Fu*, Jie Luo *. New Loss-of-Function Mutations in PCSK9 Reduce Plasma LDL Cholesterol. Arteriosclerosis, Thrombosis, and Vascular Biology, 2023. 43(7):1219-1233.
(6) Jian Xiao, Bao-Liang Song, Jie Luo*. Peroxisomes in intracellular cholesterol transport: from basic physiology to brain pathology. (Review). Exploration of Neuroprotective Therapy, 2021. 1:127–145.
校内链接
校外链接
Address: No. 1299 Xuefu Avenue, Honggutan District, Nanchang City, Jiangxi Province
Tel：+86-0791-83968485
E-mail：ibi@ncu.edu.cn
WeChat Official Account
Copyright ©INSTITUTE OF BIOMEDICAL INNOVATION, NANCHANG UNIVERSITY
NANCHANG UNIVERSITY
