个人简介

南昌大学药学院院长、学科领军人才，二级教授，博士生导师，国家级高层次人才，中国药理学会北美分会常务副主任委员，中国药理学会神经精神药理学专委会/抗衰老与老年痴呆专委会/海洋药物药理专委会常委，中国药物滥用防治协会酒精成瘾研究专委会常委，Neuropharmacology and Therapy主编，Neuroscience Bulletin，General Psychiatry，Frontiers in Aging Neuroscience，Frontiers in Pharmacology等杂志副主编。在该领域主流杂志发表论文160余篇，出版英文专著一部（Springer），参编英文专著五部。

研究方向

运用行为、生化、细胞和分子生物学技术研究酒精依赖与滥用、老年性痴呆、PTSD、焦虑、抑郁等神经精神疾病和神经退行性疾病的发病机制、分子靶标、防治策略及转化应用。

近五年代表性论文

1.Sun R, Han M, Lin Y, Ma S, Tu H, Yang X, Zhang F, Zhang HT*. Inhibition of PDE4B ameliorates cognitive defects in the model of alcoholic dementia in 3×Tg-AD mice via PDE4B/cAMP/PKA signaling. Int J Neuropsychopharmacol. 2025 Feb 8:pyaf009. PMID: 39921664.

2.Chen SC, Chen YH, Song Y, Zong SH, Wu MX, Wang W, Wang H, Zhang F, Zhou YM, Yu HY, Zhang HT*, Zhang FF*. Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice. Int J Neuropsychopharmacol. 2024 Oct 1;27(10):pyae040. PMID: 39283715.

3.Wei R, Zong F, Dong J, Zhao W, Zhang F, Wang W, Zhao S, Wang Z, Zhang F, Zhang HT*. Identification of Phosphodiesterase-7A (PDE7A) as a Novel Target for Reducing Ethanol Consumption in Mice. Int J Neuropsychopharmacol. 2024 Aug 1;27(8):pyae032. PMID: 39099166.

4.Dong J, Wei R, Zong F, Wang Z, Ma S, Zhao W, Lin Y, Zhang A, Lan G, Zhang F*, Zhang HT*. Phosphodiesterase 7 inhibitor reduces stress-induced behavioral and cytoarchitectural changes in C57BL/6J mice by activating the BDNF/TrkB pathway. Front Pharmacol. 2024 Jul 18;15:1411652. PMID: 39092219.

5.Cong YF, Liu FW, Xu L, Song SS, Shen XR, Liu D, Hou XQ, Zhang HT*. Rolipram ameliorates memory deficits and depression-like behavior in APP/PS1/tau triple transgenic mice: involvement of neuroinflammation and apoptosis via cAMP signaling. Int J Neuropsychopharmacol. 2023 Sep 25;26(9):585-598. PMID: 37490542.

6.Zhang Q, Zhao W, Hou Y, Song X, Yu H, Tan J, Zhou Y, Zhang HT*. β-Glucan attenuates cognitive impairment of APP/PS1 mice via regulating intestinal flora and its metabolites. CNS Neurosci Ther. 2023 Jun;29(6):1690-1704. PMID: 36890624.

7.Zhang FF, Wang H, Zhou YM, Yu HY, Zhang M, Du X, Wang D, Zhang F, Xu Y, Zhang JG, Zhang HT*. Inhibition of phosphodiesterase-4 in the spinal dorsal horn ameliorates neuropathic pain via cAMP-cytokine-Cx43 signaling in mice. CNS Neurosci Ther. 2022, May; 28(5):749-760. PMID: 35156776.

8.Chen Y, Wang H, Wang WZ, Wang D, Skaggs K, Zhang HT*. Phosphodiesterase 7(PDE7): A unique drug target for central nervous system diseases. Neuropharmacology. 2021 Sep 15;196:108694. PMID: 34245775.

9.Pei Y, Davies J, Zhang M, Zhang HT*. The role of synaptic dysfunction in Alzheimer’s disease. J Alzheimer’s Dis. 2020;76(1):49-62. PMID: 32417776.

10.Wang H, Zhang FF, Xu Y, Fu HR, Dan Wan X, Wang L, Chen W, Xu XY, Gao YF, Zhang JG, Zhang HT*. The phosphodiesterase-4 inhibitor roflumilast, a potential treatment for the comorbidity of memory loss and depression in Alzheimer's disease: a preclinical study in APP/PS1 transgenic mice. Int J Neuropsychopharmacol. 2020 Dec 10; 23(10):700-711. PMID: 32645141.