
邮箱:huileidong@ncu.edu.cn
地址:前湖校区南院科创楼457
研究方向:含二硫键环肽的多肽偶联药物开发与应用
个人主页:https://teacher.ncu.edu.cn/publish/093447/
教育经历
2010.09-2014.06 保定学院,学士
2014.09-2017.06 南京师范大学,硕士
2017.09-2021.06 厦门大学,博士
工作履历
2021.07-2024.06 中国科学院大学温州研究院,博士后
2024.09 -至今 南昌大学生物医学创新研究院/药学院,特聘研究员
主要研究领域:(1)多肽靶向药物的设计与开发;(2)功能性多肽组装体在生物医学中的应用;(3)自组装多肽在药物递送中的应用研究;(4)抗菌、抗炎等功能性多肽的开发与应用。
1. Huilei Dong, Jinjing Li, Hongtan Liu, Shuaimin Lu, Junjie Wu, Youming Zhang, Yizhen Yin*, Yibing Zhao, Chuanliu Wu*. Design and Ribosomal Incorporation of Noncanonical Disulfide-Directing Motifs for the Development of Multicyclic Peptide Libraries. Journal of the American Chemical Society, 2022, 114: 5116-5125. (IF=15.4)
2. Huilei Dong, Mingshui Wang, Shihui Fan, Chuanliu Wu, Chunhui Zhang, Xia Wu, Bin Xue, Yi Cao,Junjie Deng, Dan Yuan*, Junfeng Shi*. Redox-Regulated Conformational Change of Disulfide-Rich Assembling Peptides. Angewandte Chemie International Edition, 2022, 61: e2022128. (IF=16.8)
3. Huilei Dong, Xiaoting Meng, Xiaoli Zheng, Xueting Cheng, Yiwu Zheng, Yibing Zhao, Chuanliu Wu*. Design and Synthesis of Cross-Link-Dense Peptides by Manipulating Regioselective Bisthioether Cross-Linking and Orthogonal Disulfide Pairing. The Journal of Organic Chemistry, 2019, 84: 5187-5194. (IF=4.7)
4. Yuting Cai, Yatong Xiang, Huilei Dong*, Wenjing Huang, Yan Liu, Chenguang Zhao, Dan Yuan, Yun Li*, Junfeng Shi*. Injectable Self-assembling Peptide Hydrogel as a Promising Vitreous Substitute. Journal of Controlled Release, 2024.