
邮箱:pgao2@ustc.edu.cn
地址:前湖校区南院科创楼429
研究方向:肿瘤代谢和肿瘤免疫
2003年于日本大阪大学获医学博士学位,2003至2005年在美国国立癌症研究所(NCI)博士后,2005年至2010年,美国约翰霍普金斯大学医学院任博士后及助理研究员,2010年至2017年任中国科技大学教授,2017年至2022年任华南理工大学教授,2022年至2025年任南方医科大学/广东省人民医院教授;2025年至今任南昌大学第一附属医院和基础医学院双聘教授。
研究方向是肿瘤代谢和肿瘤免疫。研究肿瘤的代谢改变在肿瘤发生发展中的作用机制,包括代谢改变对肿瘤细胞命运的影响、对肿瘤微环境的重塑以及对肿瘤免疫的调控等。致力于揭示肿瘤发病的新机制,找到新靶点,为临床肿瘤治疗提供新的策略和思路。
1. Wei H, Suo C, Gu X, et al., Sun L*, Zhang H*, and Gao P*. AKR1D1 suppresses liver cancer progression by promotingbile acid metabolism-mediated NK cell cytotoxicity. Cell Metabolism. 2025.
2. Hao Y, Zhou Z, Liu R, Shen S, Liu H, Zhou Y, Sun Y, Mao Q, Zhang T, Li S, Liu Z, Sun L*, Gao P*, Zhang H*. Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance. Nat Chem Biol. 2025.
3. Yan R, Zhang P, et al., Zhang H*, Gao P*. Carnosine Regulation of Intracellular pH Homeostasis Promotes Lysosome-dependent Tumor Immunoevasion. Nature Immunology. 2024.
4. Zhu C, Yan K, et al., Gao P*, Lian Z*. Targeting OXCT1-mediated ketone metabolism reprograms macrophages to promote antitumor immunity via CD8+ T cells in hepatocellular carcinoma. Journal of Hepatology. 2024.
5. Ma W, Sun Y, et al., Gao P* and Zhang H*. OXCT1 functions as a succinyltransferase to promote hepatocellular carcinoma via succinylating LACTB. Molecular Cell. 2024
6. Sun L, Suo C, Zhang T, Shen S, et al., Zhang H*, Gao P*. ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism. Nat Chem Biol. 2023.
7. Zhang T, Sun L, et al., Gao P*, Zhang H*. ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein1. Nat Cancer. 2022.
8. Li S, Huang D, et al., Duan X*, Zhang H*, Gao P*. Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis. Nature Metabolism. 2020.
9. Zhong X, et al., Zhang H*, Zhou Q* and Gao P*. Mitochondrial dynamics is critical for the full pluripotency and embryonic developmental potential of pluripotent stem cells. Cell Metabolism. 2019.
10. Gao P*, et al., Dang CV*.c-myc suppression of mir-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature. 2009.