
邮箱:pgao2@ustc.edu.cn
地址:前湖校区南院科创楼429
研究方向:肿瘤代谢和肿瘤免疫
个人主页:
教育经历
1989-1992 解放军军医进修学院(301医院),硕士研究生
1999-2003 日本大阪大学,博士研究生
2003-2005 美国国立癌症研究所NCI/NIH免疫学部,博士后
2005-2007 约翰霍普金斯大学医学院,博士后
工作履历
2007-2010 约翰霍普金斯大学医学院,Research Associate
2010-2017 中国科学技术大学生命学院,教授
2017-2022 华南理工大学医学院,教授
2022-2025 南方医科大学/广东省人民医院,教授
2025-至今 南昌大学生物医学创新研究院/基础医学院/第一附属医院,教授
学术兼职
中国抗癌协会理事
中国细胞生物学学会细胞代谢分会委员
研究方向为肿瘤代谢和肿瘤免疫。研究肿瘤的代谢改变在肿瘤发生发展中的作用机制,包括代谢改变对肿瘤细胞命运的影响、对肿瘤微环境的重塑以及对肿瘤免疫的调控等。致力于揭示肿瘤发病的新机制,找到新靶点,为临床肿瘤治疗提供新的策略和思路。
1. Wei H, Suo C, Gu X, et al., Sun L*, Zhang H*, and Gao P*. AKR1D1 suppresses liver cancer progression by promotingbile acid metabolism-mediated NK cell cytotoxicity. Cell Metabolism. 2025.
2. Hao Y, Zhou Z, Liu R, Shen S, Liu H, Zhou Y, Sun Y, Mao Q, Zhang T, Li S, Liu Z, Sun L*, Gao P*, Zhang H*. Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance. Nat Chem Biol. 2025.
3. Yan R, Zhang P, et al., Zhang H*, Gao P*. Carnosine Regulation of Intracellular pH Homeostasis Promotes Lysosome-dependent Tumor Immunoevasion. Nature Immunology. 2024.
4. Zhu C, Yan K, et al., Gao P*, Lian Z*. Targeting OXCT1-mediated ketone metabolism reprograms macrophages to promote antitumor immunity via CD8+ T cells in hepatocellular carcinoma. Journal of Hepatology. 2024.
5. Ma W, Sun Y, et al., Gao P* and Zhang H*. OXCT1 functions as a succinyltransferase to promote hepatocellular carcinoma via succinylating LACTB. Molecular Cell. 2024
6. Sun L, Suo C, Zhang T, Shen S, et al., Zhang H*, Gao P*. ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism. Nat Chem Biol. 2023.
7. Zhang T, Sun L, et al., Gao P*, Zhang H*. ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein1. Nat Cancer. 2022.
8. Li S, Huang D, et al., Duan X*, Zhang H*, Gao P*. Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis. Nature Metabolism. 2020.
9. Zhong X, et al., Zhang H*, Zhou Q* and Gao P*. Mitochondrial dynamics is critical for the full pluripotency and embryonic developmental potential of pluripotent stem cells. Cell Metabolism. 2019.
10. Gao P*, et al., Dang CV*.c-myc suppression of mir-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature. 2009.