邮箱：jiangw.ibi@ncu.edu.cn
地址：前湖校区南院科创楼311
研究方向：干细胞分化调控、糖尿病发病机制
教育经历
2005-2010 北京大学生命科学学院细胞生物学专业，博士
2001-2005 北京大学生命科学学院生物科学专业，学士
工作履历
2025-迄今 南昌大学生物医学创新研究院/基础医学院/第二附属医院教授
2015-2026 武汉大学医学研究院教授（四级/三级）、中南医院特聘研究员
2012-2015 哈佛医学院、波士顿儿童医院，博士后
2011-2012 北卡罗莱纳大学教堂山分校医学院，博士后
学术兼职
2026-2027 《中国科学：生命科学》(英文版Science China Life Sciences) 青年编委
2022-2027 第二届湖北省医学伦理专家委员会委员
2018-2022 Science Bulletin编委成员
奖励与荣誉
湖北省杰出青年项目入选者 (2021)
中组部千人计划青年项目入选者 (2016)
HMS Epigenetics Initiative Travel Grant (2015)
Juvenile Diabetes Research Foundation (JDRF) Postdoctoral Fellowship (2012)
Beta Cell Biology Consortium (BCBC) Investigator Retreat, Scholarship (2012, 2013)
实验室的长期兴趣是结合发育生物学和遗传学/表观遗传学的基础研究，应用于人多能干细胞（胚胎干细胞ESC、诱导多能干细胞iPSC，等）分化模型来揭示疾病发生的分子机制，关注组蛋白修饰、长非编码RNA以及细胞代谢层面的细胞命运决定的分子调控机制及其失衡与疾病（糖尿病）易感/发生之间的功能关联；同时以此获得功能性细胞用于再生医学（糖尿病的细胞治疗）。研究技术主要包括人多能干细胞建立和维持、定向诱导分化（早期胚层分化、内胚层胰岛分化），基因组编辑以及组织工程等。目前的主要研究方向：（1）⼈早期胚层分化和多能性的表观代谢调控机制；（2）⻓⾮编码RNA的功能解析；（3）糖尿病易感位点的功能和机制研究；（4）⾮编码区的表达调控机制。
1. Jie Yang, Yikang Yang, Xiafei Zhang, Chenchao Yan, Liwen Jiang, Donghui Zhang, Wei Jiang*. HDAC2-mediated recruitment of METTL3 to chromatin regulates human embryonic stem cell differentiation. Cell Reports, 2025.
2. Rui Ding#, Jie Yang#, Chenchao Yan, Dan Yin*, Donghui Zhang*, Wei Jiang*. Ribo-seq provides additional evidence for cytoplasm-translated mitochondrial DNA-encoded ORFs. Science China-Life Sciences, 2025.
3. Shanshan Wen#, Ran Zheng#, Cheguo Cai*, Wei Jiang*. Chemical-based epigenetic reprogramming to advance pluripotency and totipotency. Nature Chemical Biology, 2025, 21(5):635-647.
4. Lihang Zhu#, Ran Zheng#, Shanshan Wen, Wei Jiang*. High-resolution single-cell RNA-seq data and heterogeneity analysis of human ESCs and ffEPSCs. Scientific Data, 2025, 12(1):669.
5. Heng Tang#, Shaoqing Han#, Jie Yang#, Xin Jiang, Yi Zhang, Junran Peng, Fang Wang, Xiang Li, Xiang Zhou, Wei Jiang*, Xiaocheng Weng*. Enhanced or reversible RNA N6-methyladenosine editing by red/far-red light induction. Nucleic Acids Research, 2025, 53(5): gkaf181.
6. Yinglei Li, Ran Zheng, Lai Jiang, Chenchao Yan, Ran Liu, Luyi Chen, Wenwen Jin, Yuanyuan Luo, Xiafei Zhang, Jun Tang, Zhe Dai, Wei Jiang*. A noncoding variant confers pancreatic differentiation defect and contributes to diabetes susceptibility by recruiting RXRA. Nature Communications, 2024, 15(1):9771.
7. Lai Jiang, Chenchao Yan, Ying Yi, Lihang Zhu, Zheng Liu, Donghui Zhang*, Wei Jiang*. Cell size regulates human endoderm specification through actomyosin-dependent AMOT-YAP signaling. Stem Cell Reports, 2024, 19(8):1137-1155.
8. Ying Yi, Xianchun Lan, Yinglei Li, Chenchao Yan, Jing Lv, Tianzhe Zhang, Wei Jiang*. Fatty acid synthesis and oxidation regulate human endoderm differentiation by mediating SMAD3 nuclear localization via acetylation. Developmental Cell, 2023, 58(18):1670-1687.
9. Pei Lu#, Jie Yang#, Mao Li#, Shanshan Wen, Tianzhe Zhang, Chenchao Yan, Ran Liu, Yu Xiao, Xinghuan Wang, Wei Jiang*. A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA. Genome Biology, 2023, 24(1):92.
10. Chenchao Yan, Yajing Meng, Jie Yang, Jian Chen*, Wei Jiang*. Translational landscape in human early neural fate determination. Development, 2023, 150 (6): dev201177.
11. Xianchun Lan, Song Ding, Tianzhe Zhang, Ying Yi, Conghui Li, Wenwen Jin, Jian Chen, Kaiwei Liang, Hengbin Wang, Wei Jiang*. PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression. Nature Communications, 2022, 13(1):4601.
12. Tianzhe Zhang, Ran Zheng, Mao Li, Chenchao Yan, Xianchun Lan, Bei Tong, Pei Lu, Wei Jiang*. Active endogenous retroviral elements in human pluripotent stem cells play a role in regulating host gene expression. Nucleic Acids Research, 2022, 50(9): 4959-4973.
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