邮箱：jiangw.ibi@ncu.edu.cn
地址：前湖校区南院科创楼311
研究方向：干细胞分化调控、糖尿病发病机制
南昌大学生物医学创新研究院/基础医学院/第二附属医院教授，博士生导师。2005年获北京大学生物学学士，2010年获北京大学细胞生物学博士，随后在美国北卡罗莱纳大学教堂山分校（UNC-CH）医学院、哈佛医学院/波士顿儿童医院进行博士后研究，2015年回国加入武汉大学医学研究院任教授，2016年入选中组部千人计划青年项目。组建独立实验室以来在Dev Cell、Nat Chem Biol、Nat Commun、Genome Biol、Nucleic Acids Res、Stem Cell Rep、Development等期刊发表通讯作者（含共同）论文30余篇；发表论文总引用次数超过4500次，H因子29；申请国家发明专利10余项（8项已获授权）；参与撰写中文教材/专著3部，英文专著1部。
实验室的长期兴趣是结合发育生物学和遗传学/表观遗传学的基础研究，应用于人多能干细胞（胚胎干细胞ESC、诱导多能干细胞iPSC，等）分化模型来揭示疾病发生的分子机制，关注组蛋白修饰、长非编码RNA以及细胞代谢层面的细胞命运决定的分子调控机制及其失衡与疾病（糖尿病）易感/发生之间的功能关联；同时以此获得功能性细胞用于再生医学（糖尿病的细胞治疗）。研究技术主要包括人多能干细胞建立和维持、定向诱导分化（早期胚层分化、内胚层胰岛分化），基因组编辑以及组织工程等。目前的主要研究方向：（1）⼈早期胚层分化和多能性的表观代谢调控机制；（2）⻓⾮编码RNA的功能解析；（3）糖尿病易感位点的功能和机制研究；（4）⾮编码区的表达调控机制。
1. Jie Yang, Yikang Yang, Xiafei Zhang, Chenchao Yan, Liwen Jiang, Donghui Zhang, Wei Jiang*. HDAC2-mediated recruitment of METTL3 to chromatin regulates human embryonic stem cell differentiation. Cell Reports, 2025.
2. Rui Ding#, Jie Yang#, Chenchao Yan, Dan Yin*, Donghui Zhang*, Wei Jiang*. Ribo-seq provides additional evidence for cytoplasm-translated mitochondrial DNA-encoded ORFs. Science China-Life Sciences, 2025.
3. Shanshan Wen#, Ran Zheng#, Cheguo Cai*, Wei Jiang*. Chemical-based epigenetic reprogramming to advance pluripotency and totipotency. Nature Chemical Biology, 2025, 21(5):635-647.
4. Lihang Zhu#, Ran Zheng#, Shanshan Wen, Wei Jiang*. High-resolution single-cell RNA-seq data and heterogeneity analysis of human ESCs and ffEPSCs. Scientific Data, 2025, 12(1):669.
5. Heng Tang#, Shaoqing Han#, Jie Yang#, Xin Jiang, Yi Zhang, Junran Peng, Fang Wang, Xiang Li, Xiang Zhou, Wei Jiang*, Xiaocheng Weng*. Enhanced or reversible RNA N6-methyladenosine editing by red/far-red light induction. Nucleic Acids Research, 2025, 53(5): gkaf181.
6. Yinglei Li, Ran Zheng, Lai Jiang, Chenchao Yan, Ran Liu, Luyi Chen, Wenwen Jin, Yuanyuan Luo, Xiafei Zhang, Jun Tang, Zhe Dai, Wei Jiang*. A noncoding variant confers pancreatic differentiation defect and contributes to diabetes susceptibility by recruiting RXRA. Nature Communications, 2024, 15(1):9771.
7. Lai Jiang, Chenchao Yan, Ying Yi, Lihang Zhu, Zheng Liu, Donghui Zhang*, Wei Jiang*. Cell size regulates human endoderm specification through actomyosin-dependent AMOT-YAP signaling. Stem Cell Reports, 2024, 19(8):1137-1155.
8. Ying Yi, Xianchun Lan, Yinglei Li, Chenchao Yan, Jing Lv, Tianzhe Zhang, Wei Jiang*. Fatty acid synthesis and oxidation regulate human endoderm differentiation by mediating SMAD3 nuclear localization via acetylation. Developmental Cell, 2023, 58(18):1670-1687.
9. Pei Lu#, Jie Yang#, Mao Li#, Shanshan Wen, Tianzhe Zhang, Chenchao Yan, Ran Liu, Yu Xiao, Xinghuan Wang, Wei Jiang*. A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA. Genome Biology, 2023, 24(1):92.
10. Chenchao Yan, Yajing Meng, Jie Yang, Jian Chen*, Wei Jiang*. Translational landscape in human early neural fate determination. Development, 2023, 150 (6): dev201177.
11. Xianchun Lan, Song Ding, Tianzhe Zhang, Ying Yi, Conghui Li, Wenwen Jin, Jian Chen, Kaiwei Liang, Hengbin Wang, Wei Jiang*. PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression. Nature Communications, 2022, 13(1):4601.
12. Tianzhe Zhang, Ran Zheng, Mao Li, Chenchao Yan, Xianchun Lan, Bei Tong, Pei Lu, Wei Jiang*. Active endogenous retroviral elements in human pluripotent stem cells play a role in regulating host gene expression. Nucleic Acids Research, 2022, 50(9): 4959-4973.
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