以肝再生修复与结肠癌肝转移为对象，研究（1）局部血管重构与胆管重构的发生过程，信号调控网络与靶点干预；（2）衰老对局部血管重构与胆管重构的影响；（3）类泛素化修饰ISGylation调控网络对血管重构的影响。

1. Ying Yang^#, Yuwei Zhang^#, Lu Wang, Guanyi He, Xue Yang, Jie Qing^*. Targeting p97/ VCP promotes hepatic stellate cell senescence and mitigates liver fibrosis. DNA and Cell Biology, 2025, 44(3):132-143.

2. Xue Yang^#, Yangying Ou^#, Ying Yang, Lu Wang, Yuwei Zhang, Fulan Zhao，Pixian Shui* , Jie Qing*. Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis. Experimental Biology and Medicine, 2023, 248(14):1242-1253.

3. Jie Qing^#, Yafeng Ren^#, Yuwei Zhang, Hua Zhang, Dongbo Wu, Yongyuan Ma, Yutian Chen, Mengli Yan, Xiaojuan Huang, Qinkai Wu, Maryam Mazhar, Li Wang, Jian Liu, Bi-Sen Ding*, Zhongwei Cao*. Dopamine receptor D2 antagonism normalizes profibrotic macrophage-endothelial crosstalk in non-alcoholic steatohepatitis. Journal of Hepatology, 2022, 76(2):394-406.

4. Lu Wang^#, Yuwei Zhang^#, Yafeng Ren^#, Xue Yang, Haijing Ben, Fulan Zhao, Sijin Yang, Li Wang^*, Jie Qing^*_. Pharmacological targeting of cGAS/STING -YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis, European Journal of Pharmacology, 2022, 932:175241.

5. Yuwei Zhang^#, Xue Yang^#, Tao Bi^#, Xia Wu, Lu Wang, Yafeng Ren, Yangying Ou, Chengliang Xie, Kuangjie Li, Haolong Ran, Jing Wang, Fulan Zhao, Pixian Shui, Jie Qing^*. Targeted inhibition of the immunoproteasome blocks endothelial MHC class II antigen presentation to CD4+ T Cells in chronic liver injury, International Immunopharmacology, 2022, 107:108639.

6. Han-Ying Zhu^#, Yuwei Zhang^#, Shan Su^#, Meng Wu^#, Wei Xu, Kai Chen, Lu Wang, Tong-Kuai Xi, Yan-Ni Zhang, Qin Zhou, You-Hua Xie, Lu Lu*, Jie Qing*, Ge-Min Fang*. Neutralizing SARS-CoV-2 by dimeric side chain-to-side chain cross-linked ACE2 peptide mimetics, Chemical Communications, 2022, 58(11):1804-1807.

7. Yafeng Ren^#, Yuwei Zhang^#, Lu Wang^#, Fuqian He, Mengli Yan, Xiaoheng Liu, Yangying Ou, Qinkai Wu, Tao Bi, Shiyuan Wang, Jian Liu, Bi-Sen Ding*, Li Wang*, and Jie Qing*. Selective Targeting of Vascular Endothelial YAP Activity Blocks EndMT and Ameliorates Unilateral Ureteral Obstruction-Induced Kidney Fibrosis, ACS Pharmacology & Translational Science, 2021, 4(3), 1066-1074.

8. Jie Qing, Ming Wu, Rui Luo, Jizheng Chen, Lin Cao, Debin Zeng, Luqing Shang, Junxiu Nong, Qinkai Wu, Bi-Sen Ding, Xinwen Chen*, Zihe Rao*, Lei Liu*, Zhiyong Lou*. Identification of Interferon Receptor IFNAR2 As a Novel HCV Entry Factor by Using Chemical Probes, ACS Chemical Biology, 2020, 15(5):1232-1241.

9. Jie Qing^#, Xiaoheng Liu^#, QuanWu, MengjieZhou, YuweiZhang, Maryam Mazhar, Xiaoli Huang, Li Wang, Fuqian He*. Hippo/YAP Pathway Plays a Critical Role in Effect of GDNF Against Aβ-Induced Inflammation in Microglial Cells, DNA and Cell Biology, 2020, 39(6): 1064-1071.

以肝再生修复与结肠癌肝转移为对象，研究（1）局部血管重构与胆管重构的发生过程，信号调控网络与靶点干预；（2）衰老对局部血管重构与胆管重构的影响；（3）类泛素化修饰ISGylation调控网络对血管重构的影响。

1. Ying Yang^#, Yuwei Zhang^#, Lu Wang, Guanyi He, Xue Yang, Jie Qing^*. Targeting p97/ VCP promotes hepatic stellate cell senescence and mitigates liver fibrosis. DNA and Cell Biology, 2025, 44(3):132-143.

2. Xue Yang^#, Yangying Ou^#, Ying Yang, Lu Wang, Yuwei Zhang, Fulan Zhao，Pixian Shui* , Jie Qing*. Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis. Experimental Biology and Medicine, 2023, 248(14):1242-1253.

3. Jie Qing^#, Yafeng Ren^#, Yuwei Zhang, Hua Zhang, Dongbo Wu, Yongyuan Ma, Yutian Chen, Mengli Yan, Xiaojuan Huang, Qinkai Wu, Maryam Mazhar, Li Wang, Jian Liu, Bi-Sen Ding*, Zhongwei Cao*. Dopamine receptor D2 antagonism normalizes profibrotic macrophage-endothelial crosstalk in non-alcoholic steatohepatitis. Journal of Hepatology, 2022, 76(2):394-406.

4. Lu Wang^#, Yuwei Zhang^#, Yafeng Ren^#, Xue Yang, Haijing Ben, Fulan Zhao, Sijin Yang, Li Wang^*, Jie Qing^*_. Pharmacological targeting of cGAS/STING -YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis, European Journal of Pharmacology, 2022, 932:175241.

5. Yuwei Zhang^#, Xue Yang^#, Tao Bi^#, Xia Wu, Lu Wang, Yafeng Ren, Yangying Ou, Chengliang Xie, Kuangjie Li, Haolong Ran, Jing Wang, Fulan Zhao, Pixian Shui, Jie Qing^*. Targeted inhibition of the immunoproteasome blocks endothelial MHC class II antigen presentation to CD4+ T Cells in chronic liver injury, International Immunopharmacology, 2022, 107:108639.

6. Han-Ying Zhu^#, Yuwei Zhang^#, Shan Su^#, Meng Wu^#, Wei Xu, Kai Chen, Lu Wang, Tong-Kuai Xi, Yan-Ni Zhang, Qin Zhou, You-Hua Xie, Lu Lu*, Jie Qing*, Ge-Min Fang*. Neutralizing SARS-CoV-2 by dimeric side chain-to-side chain cross-linked ACE2 peptide mimetics, Chemical Communications, 2022, 58(11):1804-1807.

7. Yafeng Ren^#, Yuwei Zhang^#, Lu Wang^#, Fuqian He, Mengli Yan, Xiaoheng Liu, Yangying Ou, Qinkai Wu, Tao Bi, Shiyuan Wang, Jian Liu, Bi-Sen Ding*, Li Wang*, and Jie Qing*. Selective Targeting of Vascular Endothelial YAP Activity Blocks EndMT and Ameliorates Unilateral Ureteral Obstruction-Induced Kidney Fibrosis, ACS Pharmacology & Translational Science, 2021, 4(3), 1066-1074.

8. Jie Qing, Ming Wu, Rui Luo, Jizheng Chen, Lin Cao, Debin Zeng, Luqing Shang, Junxiu Nong, Qinkai Wu, Bi-Sen Ding, Xinwen Chen*, Zihe Rao*, Lei Liu*, Zhiyong Lou*. Identification of Interferon Receptor IFNAR2 As a Novel HCV Entry Factor by Using Chemical Probes, ACS Chemical Biology, 2020, 15(5):1232-1241.

9. Jie Qing^#, Xiaoheng Liu^#, QuanWu, MengjieZhou, YuweiZhang, Maryam Mazhar, Xiaoli Huang, Li Wang, Fuqian He*. Hippo/YAP Pathway Plays a Critical Role in Effect of GDNF Against Aβ-Induced Inflammation in Microglial Cells, DNA and Cell Biology, 2020, 39(6): 1064-1071.