李叶华研究组

李叶华

特聘研究员、博士生导师

  • 邮箱:liyehua@ncu.edu.cn

  • 地址:前湖校区南院科创楼319

  • 研究方向:细胞死亡调控与肿瘤治疗

  • 个人主页:https://teacher.ncu.edu.cn/publish/093464/

个人简介
研究方向
研究组成员
代表性论文

教育经历

2008.09-2012.06 清华大学生命科学学院,学士

2012.08-2018.06 清华大学生命科学学院,博士

工作履历

2018.06-2024.09  北京生命科学研究所,博士后

2024.09 -至今 南昌大学生物医学创新研究院/基础医学院/第一附属医院,特聘研究员



结合类器官,研究铜死亡和铜离子代谢在肿瘤等重大疾病中的作用及调控机制。



1、Li, Yehua*; Ma, Jiahao*; Wang, Rui; Luo, Yuanhanyu; Zheng, Sanduo; Wang, Xiaodong; Zinc transporter 1 functions in copper uptake and cuproptosis, Cell Metabolism2024, 36(9): 2118-2129 (*Co-first authors)

2、Li, Yehua#; Wang, Jiawen; Wang, Rui; Wang, Xiaodong#; Gut bacteria induce IgA expression in pituitary hormone-secreting cells during aging, iScience2023, 26(10):107747 (#Corresponding)

3、Wang, Shan*; Li, Siqi*; Li, Yehua*; Jiang, Quanlong; Li, Xintong; Wang, Yalong; Han, Jing-Dong; Liu, Yuan; Chen, Ye-Guang; Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formationStem Cell Reports2021, 16(5): 1290-1301 (*Co-first authors)

4、Li, Yehua*; Liu, Yuan*; Liu, Bofeng; Wang, Jilian; Wei, Siting; Qi, Zhen; Wang, Shan; Fu, Wei; Chen, Ye-Guang; A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5(+) intestinal stem cell maintenance, Cell Discovery2018, 4(4): 49-49 (*Co-first authors)

5、Qi, Zhen*; Li, Yehua*; Zhao, Bing; Xu, Chi; Liu, Yuan; Li, Haonan; Zhang, Bingjie; Wang, Xinquan; Yang, Xiao; Xie, Wei; Li, Baojie; Han, Jing-Dong Jackie; Chen, Ye-Guang; BMP restricts stemness of intestinal Lgr5(+) stem cells by directly suppressing their signature genes, Nature Communications2017, 8(8): 13824-13824 (*Co-first authors)

6、Wu, Ye*; Li, YeHua*; Li, Xiang*; Zou, Yan; Liao, Hong-Li; Liu, Lei; Chen, Ye-Guang; Bierer, Donald; Hu, Hong-Gang; A novel peptide stapling strategy enables the retention of ring-closing amino acid side chains for the Wnt/beta-catenin signalling pathway, Chemical Science2017,11(8): 7368-7373 (*Co-first authors)

7、Zhao, Bing*; Qi, Zhen*; Li, Yehua*; Wang, Chongkai; Fu, Wei; Chen, Ye-Guang; The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells, Nature Communications2015, 6(7166) (*Co-first authors)