
邮箱:wz1103@ncu.edu.cn
地址:前湖校区南院科创楼321
研究方向:自噬及生物大分子相变
王峥,博士,生物医学创新研究院/基础医学院研究员,第二附属医院双聘研究员,博士生导师。本科和博士分别毕业于天津大学和南开大学,随后加入中国科学院生物物理研究所张宏院士课题组从事博士后工作并晋升副研究员,于2024年1月全职加入南昌大学。
主要从事细胞自噬的分子机制和生物大分子相变方向的研究,以第一和/或通讯作者身份在Molecular Cell、Developmental Cell、JCB等国际顶尖学术期刊发表多篇论文,主持国家自然科学基金原创探索计划和面上项目。
研究论文:
1. Zheng Wang*#, Chun Yang*, Dongshi Guan, Jiaqi Li, and Hong Zhang. Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates. Developmental Cell, 2023, 58: 919-932. (Featured article, highlighted in Developmental Cell entitled “Soaping up transcriptional condensates”).
2. Zheng Wang, Di Chen, Dongshi Guan, Xiaobo Liang, Jianfeng Xue, Hongyu Zhao, Guangtao Song, Jizhong Lou, Yan He, and Hong Zhang#. Material properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway. Journal of Cell Biology, 2022, 221: e202112024.
3. Zheng Wang*, Guangyan Miao*, Xue Xue*, Xiangyang Guo, Chongzhen Yuan, Zhaoyu Wang, Gangming Zhang, Yingyu Chen, Du Feng, Junjie Hu, and Hong Zhang#. (2016) The Vici syndrome protein EPG5 is a Rab7 effector that determines the fusion specificity of autophagosomes with late endosomes/lysosomes. Molecular Cell, 2016, 63: 781-795. (Recommended by “Faculty of 1000”).
4. Zheng Wang, Gangming Zhang, and Hong Zhang#. Protocol for analyzing protein liquid–liquid phase separation. Biophysics Reports, 2019, 5: 1-9.
5. Zheng Wang*, Xue Yang*, Shuang Guo, Yin Yang, Xun-Cheng Su, Yuequan Shen#, and Jiafu Long#. Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism. Journal of Biological Chemistry, 2014, 289: 27376-27385.
6. Zheng Wang*, Xue Yang*, Xinlei Chu, Jinxiu Zhang, Hao Zhou, Yuequan Shen#, and Jiafu Long#. (2012) The structural basis for the oligomerization of the N-terminal domain of SATB1. Nucleic Acids Research, 2012, 40: 4193-4202.
特邀综述:
1. Zheng Wang#, Jizhong Lou#, and Hong Zhang#. (2022) Essence determines phenomenon: Assaying the material properties of biological condensates. Journal of Biological Chemistry, 2022, 298:101782.
2. Zheng Wang, and Hong Zhang#. (2019) Phase separation, transition, and autophagic degradation of proteins in development and pathogenesis. Trends in Cell Biology, 2019, 29: 417-427. (Cover story).