
邮箱:bingzhao@ncu.edu.cn
地址:前湖校区南院科创楼323
研究方向:染色质重塑与细胞命运决定
个人主页:https://teacher.ncu.edu.cn/publish/093171/
教育经历
2005.09-2008.06 中国农业大学,学士
2008.09-2013.06 清华大学,博士
工作履历
2013.07-2015.09 清华-北大生命科学联合中心,博士后
2015.11-2017.03 辛辛那提儿童医院医学中心 ,博士后
2017.04-2023.11 复旦大学,长聘研究员、PI、博导
2023.07-至今 南昌大学,教授、PI、博导
学术兼职
第八届国务院学位办生物学、生物工程学科评议组副秘书长
中国细胞生物学学会“类器官研究与应用分会”副会长
中国细胞生物学学会“细胞结构与细胞行为分会”副秘书长
中国细胞生物学学会“细胞治疗研究与应用分会”委员
中国细胞生物学学会“标准工作委员会”委员
中国毒理学会“类器官和器官芯片分会”常务委员
中国生物医学工程学会“类器官与器官芯片分会”委员
中国微生物学会第十二届理事会委员(细胞因子与干扰素专业委员会)
Cell Regeneration《干细胞信号调控专刊》首席客座主编(期刊2024年度优秀组稿专家)
江西省细胞生物学学会常务理事、青委会主委
南昌大学生物医学创新研究院院务委员会、教授委员会委员
研究成体干细胞命运决定机制,发展类器官培育新策略。以第一/通讯作者身份于国际权威期刊Cell Research、Nature Communications、Advanced Science、Protein & Cell、Developmental Cell等发表系列性研究论文,为再生生物学和类器官技术发展提供重要基础。代表性研究成果获Nature News专访报道、Nature官网主页高亮,获国际权威综述期刊Nature Reviews Molecular Cell Biology、Nature Reviews Gastroenterology & Hepatology等高度评价。
Chen J, Zhang J, Yang L and Zhao B*. (2023) Facile suspension culture protocol of the liver biliary organoids. Bio-Design and Manufacturing, 6:74–81. (*corresponding author)
2. Chen Z, Chen C, Xiao L, Tu R, Yu M, Wang D, Kang W, Han M, Huang H, Liu H, Zhao B* and Qing G*. (2023) HILPS, a novel long non-coding RNA essential for global oxygen sensing in human. Science Advances (综合1区Top), 24;9(47):eadi1867.
3. Liang J, Wei J, Cao J, Qian J, Gao R, Li X, Wang D, Gu Y, Dong L, Yu J, Zhao B* and Wang X*. (2023) In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation. Genome Biology (生物1区Top), 24:251.
4. Luo Z, Wang B, Luo F, Guo Y, Jiang N, Wei J, Wang X, Tseng Y, Chen J, Zhao B* and Liu J*. (2023) Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screening. BMC Medicine (医学1区Top), 21:336.
5. Wang W, Yang J, Kang P, Bai J, Feng X, Huang L, Zhang Y, Wu Y, Tang B, Wang H, Jiang J, Li M, Zhao B* and Yang X. (2023) Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis. Virologica Sinica, 38:971-974.
6. Xu Y, Hu J, Lv Q, Shi C, Qiu M, Xie L, Liu W, Yang B, Shan W, Cheng Y, Zhao B* and Chen X*. (2023) Endometrium-derived mesenchymal stem cells suppress progression of endometrial cancer via the DKK1-Wnt/β-catenin signaling pathway. Stem Cell Research & Therapy, 14:159.
7. Liu G, Wei J, Li X, Tian M, Wang Z, Shen C, Sun W, Li C, Li X, Lv E, Tian S, Wang J, Xu S and Zhao B*. (2022) Near-infrared-responded high sensitivity nanoprobe for steady and visualized detection of albumin in hepatic organoids and mouse liver. Advanced Science (综合1区Top), 9:2202505.
8. Liang J, Qian J, Yang L, Chen X, Wang X, Lin X, Wang X and Zhao B*. (2022) Modeling human thyroid development by fetal tissue-derived organoid culture. Advanced Science (综合1区Top), 9:2105568.
9. Yang L, Chen J, Liang J, Zhang Y, Wang Q, Ren X, Wei J, Gong Q, Zhang J, Jiang N, Lin X, Li J and Zhao B*. (2022) Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis. Protein & Cell (生物1区Top), 13:683-688.
10. Ren X, Liang J, Zhang Y, Jiang N, Xu Y, Qiu M, Wang Y, Zhao B* and Chen X*. (2022) Single-cell transcriptomic atlas highlights origin and pathological process of human endometrioid endometrial carcinoma.
Nature Communications (综合1区Top), 13:6300.
11. Sun S, Jiang Y, Zhang Q, Pan H, Li X, Yang L, Huang M, Wei W, Wang X, Qiu M, Cao L, He H, Yu M, Liu H, Zhao B*, Jiang N*, Li R* and Lin X*. (2022) Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression. Developmental Cell (生物1区Top), 57:901–913. (Cover Story)
12. Meng F, Shen C, Yang L, Ni C, Huang J, Lin K, Cao Z, Xu S, Cui W, Wang X, Zhou B, Xiong C, Wang J and Zhao B*. (2022) Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal. Cell Regeneration (高起点期刊-卓越研究论文), 11:39.
13. Wei W, Tang X, Jiang N, Ni C, He H, Sun S, Yu M, Yu C, Qiu M, Yan D, Zhou Z, Song Y, Liu H*, Zhao B* and Lin X*. (2022) Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching. Journal of Biological Chemistry, 298:102490.
14. Huang M, Yang L, Jiang N, Dai Q, Li R, Zhou Z, Zhao B* and Lin X*. (2021) Emc3 maintains intestinal homeostasis by preserving secretory lineages. Mucosal Immunology (医学1区Top), 14:873-886. (Cover Story and 2021 Editor’s Choice)
15. Sun S, Jiang N, Jiang Y, He Q, He H, Wang X, Yang L, Li R, Liu F, Lin X and Zhao B*. (2020) Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers. Leukemia (医学1区Top), 34:3348-3358.
16. Zhao B*, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J, Zhang R and Lin X. (2020) Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids. Protein & Cell (生物1区Top), 11:771-775. (Highlighted by Nature)
17. Wang X, Ni C, Jiang N, Wei J, Liang J, Zhao B* and Lin X*. (2020) Generation of liver bipotential organoids with a small-molecule cocktail. Journal of Molecular Cell Biology, 12: 618-629.
Review Articles:
18. Li Y, Gao X, Ni C, Zhao B* and Cheng X*. (2023) The application of patient-derived organoid in the research of lung cancer. Cellular Oncology (医学1区Top), 46:503–519.
19. Wei J, Zhang W and Zhao B*. (2023) Human liver organoid: modeling liver steatosis and beyond. Cell Regeneration, 12:17.
2. Liang J, Li X, Dong Y and Zhao B*. (2022) Modeling human organ development and diseases with fetal tissue-derived organoids. Cell Transplantation, 31:1–15.
26. Lv T, Meng F, Yu M, Huang H, Lin X and Zhao B*. (2021) Defense of COVID‐19 by human organoids. Phenomics,1:113–128.