主要研究领域：（1）代谢重编程驱动免疫逃逸的机制研究；（2）免疫细胞代谢重编程在肿瘤免疫中的作用；（3）肿瘤细胞分泌蛋白或配体介导的免疫逃逸机制研究。

1. Zhang T^*, Sun L^*, Hao Y, Suo C, Shen S, Wei H, Ma W, Zhang P, Wang T, Gu X, Li ST, Chen Z, Yan R, Zhang Y, Cai Y, Zhou R, Jia W, Huang F, Gao P, Zhang H. ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1. Nat Cancer. 2022 Jan;3(1):75-89.

2. Sun L^*, Suo C^*, Zhang T^*, Shen S^*, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P. ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism. Nat Chem Biol. 2023 Dec;19(12):1492-1503.

3. Wei H, Suo C, Gu X, Shen S, Lin K, Zhu C, Yan K, Bian Z, Chen L, Zhang T, Yan R, Yang Z, Yu Y, Li Z, Liu R, He J, He Q, Zhong X, Jia W, Wong CM, Dong Z, Cao J, Sun L, Zhang H, Gao P. AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity. Cell Metab. 2025 Feb 19:S1550-4131(25)00011-7.

4. Yan R, Zhang P, Shen S, Zeng Y, Wang T, Chen Z, Ma W, Feng J, Suo C, Zhang T, Wei H, Jiang Z, Chen R, Li ST, Zhong X, Jia W, Sun L, Cang C, Zhang H, Gao P. Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion. Nat Immunol. 2024 Mar;25(3):483-495.

5. Hao Y, Zhou Z, Liu R, Shen S, Liu H, Zhou Y, Sun Y, Mao Q, Zhang T, Li ST, Liu Z, Chu Y, Sun L, Gao P, Zhang H. Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance. Nat Chem Biol. 2024 Nov 28.

主要研究领域：（1）代谢重编程驱动免疫逃逸的机制研究；（2）免疫细胞代谢重编程在肿瘤免疫中的作用；（3）肿瘤细胞分泌蛋白或配体介导的免疫逃逸机制研究。

1. Zhang T^*, Sun L^*, Hao Y, Suo C, Shen S, Wei H, Ma W, Zhang P, Wang T, Gu X, Li ST, Chen Z, Yan R, Zhang Y, Cai Y, Zhou R, Jia W, Huang F, Gao P, Zhang H. ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1. Nat Cancer. 2022 Jan;3(1):75-89.

2. Sun L^*, Suo C^*, Zhang T^*, Shen S^*, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P. ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism. Nat Chem Biol. 2023 Dec;19(12):1492-1503.

3. Wei H, Suo C, Gu X, Shen S, Lin K, Zhu C, Yan K, Bian Z, Chen L, Zhang T, Yan R, Yang Z, Yu Y, Li Z, Liu R, He J, He Q, Zhong X, Jia W, Wong CM, Dong Z, Cao J, Sun L, Zhang H, Gao P. AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity. Cell Metab. 2025 Feb 19:S1550-4131(25)00011-7.

4. Yan R, Zhang P, Shen S, Zeng Y, Wang T, Chen Z, Ma W, Feng J, Suo C, Zhang T, Wei H, Jiang Z, Chen R, Li ST, Zhong X, Jia W, Sun L, Cang C, Zhang H, Gao P. Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion. Nat Immunol. 2024 Mar;25(3):483-495.

5. Hao Y, Zhou Z, Liu R, Shen S, Liu H, Zhou Y, Sun Y, Mao Q, Zhang T, Li ST, Liu Z, Chu Y, Sun L, Gao P, Zhang H. Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance. Nat Chem Biol. 2024 Nov 28.