NOW: HOME - FACULTY - Research Groups - CHEN Yeguang Lab
E-mail：ygchen@ncu.edu.cn
Address：Room 323, Medical Science and Technology Innovation Center
Professor and doctoral supervisor at Nanchang University, Academician of the Chinese Academy of Sciences. He also serves as Vice Chairman of Biology Teaching Guidance Committee of the Ministry of Education for Higher Education Institutions, Co-convener of the 8th Biological Sciences Discipline Review Group of the Academic Degrees Committee of the State Council, President of the Asia-Pacific Cell Biology Organization, Vice President of the International Union for Cell Biology, Editor-in-Chief of Cell Regeneration, and editorial board member of journals such as Cell Research,, Open Biology, Cell Discovery, Cancer Sciences, and International Journal of Biochemistry and Cell Biology, etc.
The research group employs multidisciplinary approaches including molecular biology, cell biology, and bioinformatics, utilizing organoid technology combined with animal models and omics analyses to investigate the mechanisms underlying adult stem cell self-renewal and differentiation, as well as the pathogenesis and clinical translational potential of related diseases. Also focus on studying the molecular mechanisms and physiological/pathological functions of signaling pathways in regulating cell fate.
1. Wang X, Li SQ, Liu Y, Kuang X, Chen J, Yu P, Zhao L, Zhang Z, Huang M, Liu LS, Zhang M, Wang Y, Ji W, Li J, Zhang L, Chen YG#. （2025）Positional BMP signaling orchestrates villus length in the small intestine, Nature Communications, In press.
2. Li L, Zhang Z, Wang X, Zhao H, Liu L, Xiao Y, Hua S, Chen YG#. （2025）PRMT5 maintains homeostasis of the intestinal epithelium by modulating cell proliferation and survival, Advanced Science, e2415559.
3. Li Y, Wang X, Huang M, Wang X, Li C, Li S, Tang Y, Yu S, Wang Y, Song W, Wu W, Liu Y#, Chen YG#. （2024）BMP balances Wnt signaling via the Bcl11b-1 regulated NuRD complex to maintain intestinal stem cells, EMBO Journal, 43(23):6032.
4. Shi Q, Huang F, Wang Y, Deng H, Chen YG#.（2024）HER2 phosphorylation induced by TGF-β promotes mammary morphogenesis and breast cancer progression. Journal of Cell Biology, 223(4):e202307138.
5. Wang T, Song W, Meng Q, Qu C, GuoS, Wang Y, Tan R, Jia B#, Chen YG#. （2024）Tumorigenicity and prediction of clinical prognosis chemotherapy response of patient-derived gastric cancer organoids. Clinical and Translational Medicine, 14(2):e1588.
6. Wang Y, Lou R, Zhang Z, Xiao C, Yu S, Wei S, Liu Y, Fu W, Li B, Chen YG#. (2023) Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17, Science Advances, 9(43):eadi1827.
7. Wei X , Yu S, Zhang T, Liu L, Wang X, Wang X, Chan Y, Wang Y, Meng S, Chen YG#. (2023) MicroRNA-200 loaded lipid nanoparticles promote intestinal epithelium regeneration in canonical microRNAs-deficient mice, ACS Nano, 17(22):22901.
8. Kang K, Shi Q, Wang X, Chen YG#. (2022) Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly, Journal of Cell Biology, 221(12):e202205069.
9. Nong J, Kang K, Shi Q, Zhu X, Tao Q, Chen YG#. (2021) Phase separation of Axin organizes the β-catenin destruction complex. Journal of Cell Biology, 220(4): e202012112.
10. Wang Y, Song W, Wang J, Wang T, Xiong X, Qi Z, Fu W#, Yang X#, Chen YG#. (2020) Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. Journal of Experimental Medicine, 217(2). pii: e20191130.
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