NOW: HOME - FACULTY - Research Groups - DONG Huilei Lab
E-mail：huileidong@ncu.edu.cn
Address：Room 457, Medical Science and Technology Innovation Center
Huilei Dong, Ph.D., is an accomplished researcher in biochemistry currently serving as a Special Research Fellow and Independent Principal Investigator at Nanchang University. He earned his Ph.D. in Analytical Chemistry from Xiamen University and has been recognized as a Provincial-Level Talent in Jiangxi Province. His work is supported by competitive grants including the NSFC Young Scientist Fund. He has built an outstanding publication record, with research appearing in high-impact journals such as the Journal of the American Chemical Society (JACS) and Angewandte Chemie. His expertise covers peptide-based targeted drug design, self-assembling peptides for drug delivery, and the development of functional peptides with antimicrobial and anti-inflammatory applications.
1. Design and Development of Peptide-based Targeted Drugs: Utilizing disulfide-directed cyclization to create cell-penetrating and targeted bifunctional ultra-stable bicyclic peptides, which serve as targeting ligands for Peptide-Drug Conjugates (PDCs). Targeting sequences are identified against highly expressed cancer-specific cell surface proteins using mRNA display/phage display technologies, aiming to develop specific PDC drugs for various malignancies.
2. Functional Peptide Assemblies for Biomedical Applications: Engineering smart, redox-responsive self-assembling peptide biomaterials using disulfide bonds as molecular switches. Exploring their applications in biomedicine, including cell therapy and efficient nucleic acid drug delivery.
Development and Application of Functional Peptides (e.g., Antimicrobial, Anti-inflammatory): Screening bioactive peptides from natural sources and employing computer-aided drug design (CADD) and artificial intelligence (AI) to optimize their structures for improved drug-like properties.
1. Huilei Dong, Jinjing Li, Hongtan Liu, Shuaimin Lu, Junjie Wu, Youming Zhang, Yizhen Yin*, Yibing Zhao, Chuanliu Wu*. Design and Ribosomal Incorporation of Noncanonical Disulfide-Directing Motifs for the Development of Multicyclic Peptide Libraries. Journal of the American Chemical Society, 2022, 114: 5116-5125. (IF=15.4)
2. Huilei Dong, Mingshui Wang, Shihui Fan, Chuanliu Wu, Chunhui Zhang, Xia Wu, Bin Xue, Yi Cao,Junjie Deng, Dan Yuan*, Junfeng Shi*. Redox-Regulated Conformational Change of Disulfide-Rich Assembling Peptides. Angewandte Chemie International Edition, 2022, 61: e2022128. (IF=16.8)
3. Huilei Dong, Xiaoting Meng, Xiaoli Zheng, Xueting Cheng, Yiwu Zheng, Yibing Zhao, Chuanliu Wu*. Design and Synthesis of Cross-Link-Dense Peptides by Manipulating Regioselective Bisthioether Cross-Linking and Orthogonal Disulfide Pairing. The Journal of Organic Chemistry, 2019, 84: 5187-5194. (IF=4.7)
4. Yuting Cai, Yatong Xiang, Huilei Dong*, Wenjing Huang, Yan Liu, Chenguang Zhao, Dan Yuan, Yun Li*, Junfeng Shi*. Injectable Self-assembling Peptide Hydrogel as a Promising Vitreous Substitute. Journal of Controlled Release, 2024.
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