NOW: HOME - FACULTY - Research Groups - JIANG Wei Lab
E-mail：jiangw.ibi@ncu.edu.cn
Address：Room 311, Medical Science and Technology Innovation Center
Professor Wei Jiang is a Professor and Ph.D. Supervisor at the Institute of Biomedical Innovation, the School of Basic Medical Sciences, and the Second Affiliated Hospital of Nanchang University. He received his B.S. degree in Biology from Peking University in 2005 and his Ph.D. in Cell Biology from Peking University in 2010. He then conducted postdoctoral research at the University of North Carolina at Chapel Hill (UNC-CH) School of Medicine and at Harvard Medical School/Boston Children’s Hospital. In 2015, he returned to China and joined the Medical Research Institute of Wuhan University as a Professor.
Since establishing his independent laboratory, Professor Jiang has published more than 30 papers as corresponding or co-corresponding author in high-impact journals including Developmental Cell, Nature Chemical Biology, Nature Communications, Genome Biology, Nucleic Acids Research, Stem Cell Reports, and Development. His research publications have been cited over 4,500 times, with an H-index of 29. He has applied for more than 10 national invention patents (8 authorized) and contributed to three Chinese textbooks/monographs and one English monograph.
Our laboratory’s long-term research interest lies in integrating developmental biology with genetics and epigenetics. Using human pluripotent stem cell differentiation models (including embryonic stem cells, ESCs, and induced pluripotent stem cells, iPSCs), we aim to: 1) uncover the molecular mechanisms underlying disease pathogenesis; 2) investigate how histone modifications, long non-coding RNAs, and cellular metabolism regulate cell fate decisions, and how dysregulation of these processes contributes to disease susceptibility and onset (particularly diabetes); 3) develop functional cells for use in regenerative medicine, such as cell-based therapies for diabetes.
The research techniques primarily include the establishment and maintenance of human pluripotent stem cells, directed differentiation (early germ layer differentiation and pancreatic islet lineage differentiation), genome editing, and tissue engineering. Current major research directions include:
1) Epigenetic and metabolic regulation of human early germ layer differentiation and pluripotency; 2) Functional analysis of long non-coding RNAs; 3) Functional and mechanistic studies of diabetes susceptibility loci; 4) Mechanisms of gene expression regulation in non-coding genomic regions.
1. Jie Yang, Yikang Yang, Xiafei Zhang, Chenchao Yan, Liwen Jiang, Donghui Zhang, Wei Jiang*. HDAC2-mediated recruitment of METTL3 to chromatin regulates human embryonic stem cell differentiation. Cell Reports, 2025.
2. Rui Ding#, Jie Yang#, Chenchao Yan, Dan Yin*, Donghui Zhang*, Wei Jiang*. Ribo-seq provides additional evidence for cytoplasm-translated mitochondrial DNA-encoded ORFs. Science China-Life Sciences, 2025.
3. Shanshan Wen#, Ran Zheng#, Cheguo Cai*, Wei Jiang*. Chemical-based epigenetic reprogramming to advance pluripotency and totipotency. Nature Chemical Biology, 2025, 21(5):635-647.
4. Lihang Zhu#, Ran Zheng#, Shanshan Wen, Wei Jiang*. High-resolution single-cell RNA-seq data and heterogeneity analysis of human ESCs and ffEPSCs. Scientific Data, 2025, 12(1):669.
5. Heng Tang#, Shaoqing Han#, Jie Yang#, Xin Jiang, Yi Zhang, Junran Peng, Fang Wang, Xiang Li, Xiang Zhou, Wei Jiang*, Xiaocheng Weng*. Enhanced or reversible RNA N6-methyladenosine editing by red/far-red light induction. Nucleic Acids Research, 2025, 53(5): gkaf181.
6. Yinglei Li, Ran Zheng, Lai Jiang, Chenchao Yan, Ran Liu, Luyi Chen, Wenwen Jin, Yuanyuan Luo, Xiafei Zhang, Jun Tang, Zhe Dai, Wei Jiang*. A noncoding variant confers pancreatic differentiation defect and contributes to diabetes susceptibility by recruiting RXRA. Nature Communications, 2024, 15(1):9771.
7. Lai Jiang, Chenchao Yan, Ying Yi, Lihang Zhu, Zheng Liu, Donghui Zhang*, Wei Jiang*. Cell size regulates human endoderm specification through actomyosin-dependent AMOT-YAP signaling. Stem Cell Reports, 2024, 19(8):1137-1155.
8. Ying Yi, Xianchun Lan, Yinglei Li, Chenchao Yan, Jing Lv, Tianzhe Zhang, Wei Jiang*. Fatty acid synthesis and oxidation regulate human endoderm differentiation by mediating SMAD3 nuclear localization via acetylation. Developmental Cell, 2023, 58(18):1670-1687.
9. Pei Lu#, Jie Yang#, Mao Li#, Shanshan Wen, Tianzhe Zhang, Chenchao Yan, Ran Liu, Yu Xiao, Xinghuan Wang, Wei Jiang*. A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA. Genome Biology, 2023, 24(1):92.
10. Chenchao Yan, Yajing Meng, Jie Yang, Jian Chen*, Wei Jiang*. Translational landscape in human early neural fate determination. Development, 2023, 150 (6): dev201177.
11. Xianchun Lan, Song Ding, Tianzhe Zhang, Ying Yi, Conghui Li, Wenwen Jin, Jian Chen, Kaiwei Liang, Hengbin Wang, Wei Jiang*. PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression. Nature Communications, 2022, 13(1):4601.
12. Tianzhe Zhang, Ran Zheng, Mao Li, Chenchao Yan, Xianchun Lan, Bei Tong, Pei Lu, Wei Jiang*. Active endogenous retroviral elements in human pluripotent stem cells play a role in regulating host gene expression. Nucleic Acids Research, 2022, 50(9): 4959-4973.
校内链接
校外链接
Address: No. 1299 Xuefu Avenue, Honggutan District, Nanchang City, Jiangxi Province
Tel：+86-0791-83968485
E-mail：ibi@ncu.edu.cn
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