NOW: HOME - FACULTY - Research Groups - ZHANG Hanting Lab
E-mail：hantingzhang@ncu.edu.cn
Address：Room 225, Medical Science and Technology Innovation Center
Dean of the School of Pharmacy, Nanchang University; Class II Professor and Doctoral Supervisor; Executive Vice-Chair of the North American Branch of the Chinese Pharmacological Society; Standing Committee Member of the Neuropharmacology, Anti-Aging & Alzheimer's Disease, and Marine Drug Pharmacology Committees of the Chinese Pharmacological Society; Standing Committee Member of the Alcohol Addiction Research Committee of the Chinese Association of Drug Abuse Prevention and Treatment; Editor-in-Chief of Neuropharmacology and Therapy; Associate Editor of Neuroscience Bulletin, General Psychiatry, Frontiers in Aging Neuroscience, Frontiers in Pharmacology, and other journals. Has published over 160 papers in mainstream journals in the field, authored one English monograph (Springer), and contributed to five English monographs.
Employing behavioral, biochemical, cellular, and molecular biology techniques to study the pathogenesis, molecular targets, therapeutic strategies, and translational applications of neuropsychiatric disorders and neurodegenerative diseases such as alcohol dependence and abuse, Alzheimer's disease, PTSD, anxiety, and depression.
1.Sun R, Han M, Lin Y, Ma S, Tu H, Yang X, Zhang F, Zhang HT*. Inhibition of PDE4B ameliorates cognitive defects in the model of alcoholic dementia in 3×Tg-AD mice via PDE4B/cAMP/PKA signaling. Int J Neuropsychopharmacol. 2025 Feb 8:pyaf009. PMID: 39921664.
2.Chen SC, Chen YH, Song Y, Zong SH, Wu MX, Wang W, Wang H, Zhang F, Zhou YM, Yu HY, Zhang HT*, Zhang FF*. Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice. Int J Neuropsychopharmacol. 2024 Oct 1;27(10):pyae040. PMID: 39283715.
3.Wei R, Zong F, Dong J, Zhao W, Zhang F, Wang W, Zhao S, Wang Z, Zhang F, Zhang HT*. Identification of Phosphodiesterase-7A (PDE7A) as a Novel Target for Reducing Ethanol Consumption in Mice. Int J Neuropsychopharmacol. 2024 Aug 1;27(8):pyae032. PMID: 39099166.
4.Dong J, Wei R, Zong F, Wang Z, Ma S, Zhao W, Lin Y, Zhang A, Lan G, Zhang F*, Zhang HT*. Phosphodiesterase 7 inhibitor reduces stress-induced behavioral and cytoarchitectural changes in C57BL/6J mice by activating the BDNF/TrkB pathway. Front Pharmacol. 2024 Jul 18;15:1411652. PMID: 39092219.
5.Cong YF, Liu FW, Xu L, Song SS, Shen XR, Liu D, Hou XQ, Zhang HT*. Rolipram ameliorates memory deficits and depression-like behavior in APP/PS1/tau triple transgenic mice: involvement of neuroinflammation and apoptosis via cAMP signaling. Int J Neuropsychopharmacol. 2023 Sep 25;26(9):585-598. PMID: 37490542.
6.Zhang Q, Zhao W, Hou Y, Song X, Yu H, Tan J, Zhou Y, Zhang HT*. β-Glucan attenuates cognitive impairment of APP/PS1 mice via regulating intestinal flora and its metabolites. CNS Neurosci Ther. 2023 Jun;29(6):1690-1704. PMID: 36890624.
7.Zhang FF, Wang H, Zhou YM, Yu HY, Zhang M, Du X, Wang D, Zhang F, Xu Y, Zhang JG, Zhang HT*. Inhibition of phosphodiesterase-4 in the spinal dorsal horn ameliorates neuropathic pain via cAMP-cytokine-Cx43 signaling in mice. CNS Neurosci Ther. 2022, May; 28(5):749-760. PMID: 35156776.
8.Chen Y, Wang H, Wang WZ, Wang D, Skaggs K, Zhang HT*. Phosphodiesterase 7(PDE7): A unique drug target for central nervous system diseases. Neuropharmacology. 2021 Sep 15;196:108694. PMID: 34245775.
9.Pei Y, Davies J, Zhang M, Zhang HT*. The role of synaptic dysfunction in Alzheimer’s disease. J Alzheimer’s Dis. 2020;76(1):49-62. PMID: 32417776.
10.Wang H, Zhang FF, Xu Y, Fu HR, Dan Wan X, Wang L, Chen W, Xu XY, Gao YF, Zhang JG, Zhang HT*. The phosphodiesterase-4 inhibitor roflumilast, a potential treatment for the comorbidity of memory loss and depression in Alzheimer's disease: a preclinical study in APP/PS1 transgenic mice. Int J Neuropsychopharmacol. 2020 Dec 10; 23(10):700-711. PMID: 32645141.
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