个人简介

李叶华，男，主要从事细胞死亡及肠道干细胞和类器官的研究，以第一作者或者共同第一作者身份在Cell Metabolism，Nature Communications, Cell Discovery和Stem Cell Reports等国际著名期刊发表文章。

学习与工作经历：

2024.01 -至今：南昌大学生物医学创新研究院 特聘研究员

2018.06-2024.09： 北京生命科学研究所 博士后

2012.08-2018.06： 清华大学生命科学学院 博士

2008.09-2012.06： 清华大学生命科学学院 学士

研究方向

结合类器官研究铜死亡和铜离子代谢在肿瘤等重大疾病中的作用及调控机制

代表性论文

1、Li, Yehua*; Ma, Jiahao*; Wang, Rui; Luo, Yuanhanyu; Zheng, Sanduo; Wang, Xiaodong; Zinc transporter 1 functions in copper uptake and cuproptosis, Cell Metabolism, 2024, 36(9): 2118-2129 (*Co-first authors)

2、Li, Yehua#; Wang, Jiawen; Wang, Rui; Wang, Xiaodong#; Gut bacteria induce IgA expression in pituitary hormone-secreting cells during aging, iScience, 2023, 26(10):107747 (#Corresponding)

3、Wang, Shan*; Li, Siqi*; Li, Yehua*; Jiang, Quanlong; Li, Xintong; Wang, Yalong; Han, Jing-Dong; Liu, Yuan; Chen, Ye-Guang; Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formation, Stem Cell Reports, 2021, 16(5): 1290-1301 (*Co-first authors)

4、Li, Yehua*; Liu, Yuan*; Liu, Bofeng; Wang, Jilian; Wei, Siting; Qi, Zhen; Wang, Shan; Fu, Wei; Chen, Ye-Guang; A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5(+) intestinal stem cell maintenance, Cell Discovery, 2018, 4(4): 49-49 (*Co-first authors)

5、Qi, Zhen*; Li, Yehua*; Zhao, Bing; Xu, Chi; Liu, Yuan; Li, Haonan; Zhang, Bingjie; Wang, Xinquan; Yang, Xiao; Xie, Wei; Li, Baojie; Han, Jing-Dong Jackie; Chen, Ye-Guang; BMP restricts stemness of intestinal Lgr5(+) stem cells by directly suppressing their signature genes, Nature Communications, 2017, 8(8): 13824-13824 (*Co-first authors)

6、Wu, Ye*; Li, YeHua*; Li, Xiang*; Zou, Yan; Liao, Hong-Li; Liu, Lei; Chen, Ye-Guang; Bierer, Donald; Hu, Hong-Gang; A novel peptide stapling strategy enables the retention of ring-closing amino acid side chains for the Wnt/beta-catenin signalling pathway, Chemical Science, 2017,11(8): 7368-7373 (*Co-first authors)

7、Zhao, Bing*; Qi, Zhen*; Li, Yehua*; Wang, Chongkai; Fu, Wei; Chen, Ye-Guang; The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells, Nature Communications, 2015, 6(7166) (*Co-first authors)

主持项目

1.国家自然科学基金青年科学基金，项目名称：细胞铜死亡关键参与因子Slc30a1/ZNT1的工作机制和生理功能研究，课题负责人：李叶华，2024-2025

科研获奖及专利

1. 陈晔光; 李叶华; 刘媛 ; 肠上皮类器官无生长因子培养方法, 2021-04-13, 中国, CN201810083614.9