个人简介

张文华，博士，研究员，博士生导师，南昌大学生物医学创新研究院副院长，国家级、省级人才。兼任中国生理学会转化神经科学专业委员会委员，中国神经科学学会应激神经生物学分会委员/副秘书，中国神经科学学会麻醉与脑功能学会青年委员，江西省青年科技协会理事/副秘书长。近年来研究成果以第一作者或通讯作者身份在Biological Psychiatry，Advanced Materials，Nature Communications，Science Bulletin等期刊发表论文30余篇。论文近5年被引1700余次，单篇最高被引360次（Google Scholar数据），其中1篇论文被Faculty1000列为推荐论文，2篇论文入选ESI高被引论文，1篇论文入选热点论文。先后主持国家自然科学基金优青、面上、青年基金；以及江西省双千项目、江西省杰青、重点等省部级项目；作为项目骨干参与科技部重大项目（1170万）。获2020年江西省自然科学二等奖（第二完成人）。

研究方向

利用神经示踪、电生理、光纤记录、光遗传学、化学遗传学等前沿实验技术，在分子、突触、细胞、环路以及动物行为水平等多个层面解析焦虑症、抑郁症等精神疾病的发病机制，并基于中医药活性成分和纳米载药材料建立相应的疾病防治策略。

代表性论文

1. Wen-Hua Zhang, Jun-Yu Zhang, Andrew Holmes, Bing-Xing Pan*. Amygdala circuit substrates for stress adaptation and adversity. Biological Psychiatry, 2021, 89(9):847-856 (IF2021=12.81)，封面文章

2. Wen-Hua Zhang, Wei-Zhu Liu, Ye He, Wen-Jie You, Jun-Yu Zhang, Hong Xu, Xiao-Li Tian, Bao-Ming Li, Lin Mei, Andrew Holmes, Bing-Xing Pan*. Chronic stress causes projection-specific adaptation of amygdala neurons via small-conductance calcium-activated potassium channel downregulation. Biological Psychiatry, 2019, 85(10):812-828 (IF2019=12.09)，（Preview by Ming-Hu Han, Biological Psychiatry, 85:784-786, 2019）

3. Zhi-Heng Zheng#, Jiang-Long Tu#, Xiao-Han Li, Qing Hua, Wei-Zhu Liu, Yu Liu, Bing-Xing Pan, Ping Hu, Wen-Hua Zhang*. Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala. Brain Behavior and Immunity, 2021, 91:505-518. (IF2021=19.23), ESI全球1‰热点论文，1%高被引论文

4. Yu Liu#, Ping Hu#, Zhi-Heng Zheng, Da Zhong, Wei-Chang Xie, Zhi-Bo Tang, Bing-Xing Pan*, Jun Luo*, Wen-Hua Zhang*, Xiao-Lei Wang*. Photoresponsive Vaccine-Like CAR-M System with High- Efficiency Central Immune Regulation for Inflammation-related Depression. Advanced Materials, 2022, 34(11):e2108525. (IF2022=29.4)

5. Xia Qin, Han-Qing Pan, Shou-He Huang, Jia-Xin Zou, Zhi-Heng Zheng, Xiao-Xuan Liu, Wen-Jie You, Zhi-Peng Liu, Jun-Li Cao, Wen-Hua Zhang*, Bing-Xing Pan*. GABAA(δ) receptor hypofunction in the amygdala-hippocampal circuit underlies stress-induced anxiety. Science Bulletin, 2022, 67(1):97-110 (IF2022=18.9)

6. Wei-Zhu Liu#, Wen-Hua Zhang#, Zhi-Heng Zheng, Jia-Xin Zou, Xiao-Xuan Liu, Shou-He Huang, Wen-Jie You, Ye He, Jun-Yu Zhang, Xiao-Dong Wang, Bing-Xing Pan*. Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety. Nature Communications, 2020, 11:2221 (IF2020=14.92)，Faculty Opinions (原F1000 prime)推荐论文，ESI全球1%高被引论文

7. Li-Guo Jin#, Ping Hu#, Yin-Yin Wang, Luo-Jia Wu, Kang Qin, Hao-Xin Cheng, Shu-Hua Wang, Bing-Xing Pan, Hong-Bo Xin, Wen-Hua Zhang*, Xiao-Lei Wang*. Fast-Acting Black-Phosphorus-Assisted Depression Therapy with Low Toxicity. Advanced Materials, 2020, 32(2):e1906050. (IF2020=30.85)

8. Wei-Zhu Liu, Shou-He Huang, Yu Wang, Chun-Yan Wang, Han-Qing Pan, Ke Zhao, Ping Hu, Bing-Xing Pan*, Wen-Hua Zhang*. Medial prefrontal cortex input to basolateral amygdala controls acute stress-induced short-term anxiety-like behavior in mice. Neuropsychopharmacology, 2023, 48:734-744. (IF2022=7.6)

9. Wei-Zhu Liu#, Chun-Yan Wang#, Yu Wang, Wei-Xiang Zhong, Mei-Ting Cai, Tian Liu, Zhi-Hao Wang, Han-Qing Pan, Wen-Hua Zhang* and Bing-Xing Pan*. Circuit- and laminar-specific regulation of medial prefrontal neurons by chronic stress. Cell and Bioscience, 2023, 13:90, (IF2022=7.5)

10. Zhi-Heng Zheng#, Xing-Cheng Lin#, Ying Lu, Shi-Rui Cao, Xu-Kai Liu, Dong Lin, Fan-Hua Yang, Yang-Bo Zhang, Jiang-Long Tu, Bing-Xing Pan, Ping Hu*, Wen-Hua Zhang*. Harmine exerts anxiolytic effects by regulating neuroinflammation and neuronal plasticity in the basolateral amygdala. International Immunopharmacology, 2023, 119:110208, (IF2021=5.6)

11. Ping Hu#, Ying Lu#, Bing-Xing Pan*, Wen-Hua Zhang*. New insights into the pivotal role of the amygdala in inflammation-related depression and anxiety disorder. International Journal of Molecular Sciences, 2022, 23(19):11076 (IF2022=5.6), Top Downloaded Papers in 2022

12. Shou-He Huang#, Wei-Zhu Liu#, Xia Qin, Chen-Yi Guo, Qing-Cheng Xiong, Yu Wang, Ping Hu, Bing-Xing Pan*, Wen-Hua Zhang*. Association of increased amygdala activity with stress-induced anxiety but not social avoidance behavior in mice. Neuroscience Bulletin, 2022, 38(1)16-28, (IF2022=5.6)