个人简介

南昌大学教授，博士生导师，中国科学院院士。兼任教育部高校生物教学指导委员会副主任、国务院学位委员会第八届生物学科评议组共同召集人、亚太细胞生物学组织理事长、国际细胞生物学联盟副理事长、Cell Regeneration杂志主编及Cell Res、Open Biol、Cell Discovery、Cancer Sciences、Intl J Biochem Cell Biol等杂志编委。

研究方向

主要运用分子生物学、细胞生物学、生物信息学等多学科手段，通过类器官技术，结合动物模型和组学检测等方法研究成体干细胞自我更新和分化的机制，并探索相关疾病发生发展的机理和临床转化应用前景。同时研究信号调控细胞命运的分子机制和生理病理功能。

代表性论文

1. Wang X, Li SQ, Liu Y, Kuang X, Chen J, Yu P, Zhao L, Zhang Z, Huang M, Liu LS, Zhang M, Wang Y, Ji W, Li J, Zhang L, Chen YG^#. （2025）Positional BMP signaling orchestrates villus length in the small intestine, Nature Communications, In press.

2. Li L, Zhang Z, Wang X, Zhao H, Liu L, Xiao Y, Hua S, Chen YG^#. （2025）PRMT5 maintains homeostasis of the intestinal epithelium by modulating cell proliferation and survival, Advanced Science, e2415559.

3. Li Y, Wang X, Huang M, Wang X, Li C, Li S, Tang Y, Yu S, Wang Y, Song W, Wu W, Liu Y^#, Chen YG^#. （2024）BMP balances Wnt signaling via the Bcl11b-1 regulated NuRD complex to maintain intestinal stem cells, EMBO Journal, 43(23):6032.

4. Shi Q, Huang F, Wang Y, Deng H, Chen YG^#.（2024）HER2 phosphorylation induced by TGF-β promotes mammary morphogenesis and breast cancer progression. Journal of Cell Biology, 223(4):e202307138.

5. Wang T, Song W, Meng Q, Qu C, GuoS, Wang Y, Tan R, Jia B^#, Chen YG^#. （2024）Tumorigenicity and prediction of clinical prognosis chemotherapy response of patient-derived gastric cancer organoids. Clinical and Translational Medicine, 14(2):e1588.

6. Wang Y, Lou R, Zhang Z, Xiao C, Yu S, Wei S, Liu Y, Fu W, Li B, Chen YG^#. (2023) Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17, Science Advances, 9(43):eadi1827.

7. Wei X , Yu S, Zhang T, Liu L, Wang X, Wang X, Chan Y, Wang Y, Meng S, Chen YG^#. (2023) MicroRNA-200 loaded lipid nanoparticles promote intestinal epithelium regeneration in canonical microRNAs-deficient mice, ACS Nano, 17(22):22901.

8. Kang K, Shi Q, Wang X, Chen YG^#. (2022)  Dishevelled  phase separation promotes Wnt signalosome assembly and destruction complex disassembly, Journal of Cell Biology, 221(12):e202205069.

9. Nong J, Kang K, Shi Q, Zhu X, Tao Q, Chen YG^#. (2021)  Phase separation of Axin organizes the β-catenin destruction complex. Journal of Cell Biology, 220(4): e202012112.

10. Wang Y, Song W, Wang J, Wang T, Xiong X, Qi Z, Fu W^#, Yang X^#, Chen YG^#. (2020) Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. Journal of Experimental Medicine, 217(2). pii: e20191130