个人简介

Ansgar Poetsch教授于1999年获德国达姆施塔特工业大学生物物理化学博士学位。于2002年至2019年期间先后在德国波鸿鲁尔大学、英国普利茅斯大学担任副教授。曾在德国、西班牙及中国等国家主持完成17项基金项目，在Nature, Nat. Communications, EMBO Journal等SCI期刊上发表论文102篇，作为第一和通讯作者发表文章42篇，参与编写专著6部，在欧洲获批2项专利。曾获中国科学院院长奖、自然科学人类蛋白组组织青年科学家奖、英国高等教育学院高等教育学院奖、德国联邦教育研究部青年研究团队奖、江西省级人才。担任德国应用微生物学会成员、德国蛋白质组学会(HUPO)成员，Biology编辑及审稿人，Frontiers in Microbiology客座编辑，Nature Protocols、Proteomics、Journal of Proteome Research等学术刊物的特邀审稿人，DFG、BBSRC、EU等基金会特邀审稿人等职务。

研究方向

基于质谱技术、蛋白组学、代谢组学的重大疾病生物标志物寻找，包括氧化应激与衰老研究，基于蛋白质组学研究线粒体相关细胞外囊泡在衰老心肌细胞中调控机制；以及基于质谱与蛋白质组学的精子研究，鉴定精子中未知蛋白，解析候选未知蛋白在精子中的功能，探究翻译后修饰在精子中的功能。

近五年代表性论文

1. Chen, X.; Poetsch, A. , The Role of Cdo1 in Ferroptosis and Apoptosis in Cancer. Biomedicines, 2024, 12, 918.

2. Jian, H.; Poetsch, A. , CASZ1: Current Implications in Cardiovascular Diseases and Cancers. Biomedicines, 2023, 11, 2079.

3. Schmidt, A., Frei, J., Poetsch, A. , et al., MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation. Front Cell Dev Biol, 2022, 10: p. 941493.

4. Luenenschloss, A., Veld, F., Albaum, S., Neddermann, T., Wendisch, V., Poetsch, A., et al.,Functional Genomics Uncovers Pleiotropic Role of Rhomboids in Corynebacterium glutamicum. Frontiers in Microbiology, 2022. 13.

5. Marchesini MI, Poetsch A., Guidolin L.S., Comerci D.J. Brucella abortus Encodes an Active Rhomboid Protease: Proteome Response after Rhomboid Gene Deletion. Microorganisms, 2022;10(1).

6. Trötschel, C., Hamzeh, H., Alvarez, L., Pascal, R., Lavryk, F., Poetsch,A., et al., Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation. Embo j, 2020. 39(4): p. e102723.

7. Chaoyun，Chen., Harst, W., Wuxin Y., Poetsch, A., et al., Proteomic study uncovers molecular principles of single-cell-level phenotypic heterogeneity in lipid storage of Nannochloropsis oceanica. Biotechnol Biofuels, 2019. 12: p. 21.

8. Ogorodnikov, A., Poetsch, A., et al., Transcriptome 3′end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma. Nature Communications, 2018. 9(1): p. 5331.

9. Guevara, C.R.;Philipp, O.;Hamann, A.;Werner, A.;Osiewacz, H.D.;Rexroth, S.;Rögner, M., Poetsch, A., et al., Global Protein Oxidation Profiling Suggests Efficient Mitochondrial Proteome Homeostasis During Aging. Mol Cell Proteomics, 2016. 15(5): p. 1692-709.

10. Cerletti, M., Paggi, R.A., Guevara, C.R., Poetsch, A., et al., Global role of the membrane protease LonB in Archaea: Potential protease targets revealed by quantitative proteome analysis of a lonB mutant in Haloferax volcanii. J Proteomics, 2015. 121: p. 1-14.

11. Vera, M., Krok, B., Bellenberg, S., Sand. W., Poetsch, A., Shotgun proteomics study of early biofilm formation process of Acidithiobacillus ferrooxidans ATCC 23270 on pyrite. Proteomics, 2013. 13(7): p. 1133-44.

12. Trotschel, C., et al., Protein turnover quantification in a multilabeling approach: from data calculation to evaluation. Mol Cell Proteomics, 2012. 11(8): p. 512-26.

13. Rietschel, B., Tabiwang, N., Arrey, B., Meyer1, A., Bornemann1, S., Schuerken1, M., Poetsch, A., et al., Elastase digests: new ammunition for shotgun membrane proteomics. Mol Cell Proteomics, 2009. 8(5): p. 1029-43.

14. Gertz, M., Seelert, H., Dencher, N., Poetsch, A., et al., Interactions of rotor subunits in the chloroplast ATP synthase modulated by nucleotides and by Mg2+. Biochim Biophys Acta, 2007. 1774(5): p. 566-74.

15. Fischer, F., Wolters, D., Rögner, M., Poetsch, A., et al., Toward the complete membrane proteome - High coverage of integral membrane proteins through transmembrane peptide detection. Molecular & Cellular Proteomics, 2006. 5(3): p. 444-453.

16. Poetsch, A., L. Molday, and R. Molday, The cGMP-gated channel and related glutamic acid-rich proteins interact with peripherin-2 at the rim region of rod photoreceptor disc membranes. Journal of Biological Chemistry, 2001. 276(51): p. 48009-48016.

17. Seelert, H., Poetsch, A., et al., Structural biology - Proton-powered turbine of a plant motor. Nature, 2000. 405(6785): p. 418-419