个人简介

南昌大学/清华大学教授，博士生导师。中国科学院院士、发展中国家科学院院士。Cell Regeneration 杂志主编及Cell Research、Open Biology、Cell Discovery、Bioessays、Research、Journal of Experimental & Clinical Cancer Research、 Cancer Sciences 等期刊编委。

研究方向

主要运用分子生物学、细胞生物学、生物信息学等多学科手段，通过类器官技术，结合动物模型和组学检测等方法研究成体干细胞自我更新和分化的机制以及TGF-β、Wnt、BMP等信号调控细胞命运的分子机理和生理病理功能；创建一系列类器官培养体系和肿瘤类器官体外药物筛选平台，探索相关疾病发生发展的机理和临床转化应用前景。

近五年代表性论文

1. Li YH, Wang XD, Huang MM, Wang X, Li CL, Li SQ, Tang YH, Yu SC, Wang YL, Song WL, Wu W, Liu Y*, Chen YG*. 2024 BMP balances Wnt signaling via the Bcl11b-1 regulated NuRD complex to maintain intestinal stem cells. EMBO J, 43(23): 6032.

2. Huang M, Wang X, Zhang M, Liu Y, Chen YG^#. 2024 METTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium. Cell Regeneration, 13(1):14.

3. Shi QN, Huang F, Wang YL, Deng HT, Chen YG*. 2024 HER2 phosphorylation induced by TGF-β promotes mammary morphogenesis and breast cancer progression. Journal of Cell Biology, 2024, 223(4): e202307138.

4. Cui Y, Shi Q, Song P, Tong J, Cheng Z, Zhang H, Wang X, Zheng Y, Wu Y, Wan M, Li S, Zhao X, Tong Z, Yu Z, Gao S, Chen YG^#, Gao GF^#. 2024 Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling. Journal of Experimental Medicine, 221(8):e20231512.

5. Nong J, Shen S, Hong F, Xiao F, Meng L, Li P, Lei X, Chen YG^#. 2024 Verteporfin inhibits TGF-β signaling by disrupting the Smad2/3-Smad4 interaction. Molecular Biology of Cell, mbcE24020073.

6. Wang T#, Song WL#, Meng QY#*,Qu CQ, Guo SH, Wang YL, Tan RH, Jia BQ*, Chen YG*. 2024 Tumorigenicity and prediction of clinical prognosis chemotherapy response of patient-derived gastric cancer organoids, Clinical and Translational Medicine, 14(2): e1588.

7. Wang Y#, Huang MM#, Mu XY#, Song WL, Guo Q, Zhang M, Liu Y*, Chen YG*, Ge L*. 2024 TMED10-mediated unconventional secretion of IL-33 regulates intestinal epithelium differentiation and homeostasis. Cell Research, 34(3): 258-261

8. Wang YL#, Lou RY#, Zhang Z, Xiao CY, Yu SC, Wei ST, Liu Y, Fu W, Li BJ, Chen YG*. 2023 Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17. Science Advance, 9(43): eadi1827.

9. Wei X, Yu SC, Zhang TH, Liu LS, Wang X, Wang XD, chan YS, Wang YM, Meng S, Chen YG*. 2023 MicroRNA-200 loaded lipid nanoparticles promote intestinal epithelium regeneration in canonical microRNAs-deficient mice. ACS Nano, 17(22): 22901.

10. Wei S, Li M, Song W, Liu J, Yu S, Wang Y, Zhang M, Du H, Liu Y, Liu H, Fu W, Li B, Chen YG^# 2023 The cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling. Cell Regeneration, 12(1):30.

11. Liu LS#, Wang YL#, Yu SC#, Liu HD, Li YH, Hua s, Chen YG*. 2023 TGF-β promotes inflammation and tumorigenesis in Smad4-deficient intestinal epithelium in a YAP-dependent manner. Advanced Science, 10(23): e2300708.

12. Liu Y, Huang M, Wang X, Liu Z, Li S, Chen YG. 2023 Segregation of the stemness program from the proliferation program in intestinal stem cells. Stem Cell Reports, 18(5):1196-1210.

13. Wang X, Hong F, Li H, Wang Y, Zhang M, Lin S, Liang H, Zhou H, Liu Y, Chen YG^#. 2023 Cross-species single-cell transcriptomic analysis of animal gastric antrum reveals intense porcine mucosal immunity. Cell Regeneration, 12(1):27.

14. Kang KX#, Shi QN#, Wang X, Chen YG*. 2022 Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly. Journal of Cell Biology, 2022, 221(12): e202205069.

15. Zhao L, Song W, Chen YG^#. 2022 Mesenchymal-epithelial interaction regulates gastrointestinal tract development in mouse embryos. Cell Reports, 40(2):111053.

16. Nong JX#, Kang KX#, Shi QN#, Zhu XC, Tao QH, Chen YG*. 2021 Phase separation of Axin organizes the β-catenin destruction complex. Journal of Cell Biology, 220(4): e202012112.

17. Wang T, Zhang N, Fan S, Zhao L, Song S, Gong Y, Shen Q, Zhang C, Ren P, Lin C, Fu W, Gao GF, Ma S, Bi Y, Chen YG^#. 2021 Establishment of human distal bronchial organoids for SARS-CoV-2 infection. Cell Discovery, 7(1):108.

18. Wang S, Li S, Li Y, Jiang Q, Li X, Wang Y, Han JD, Liu Y^#, Chen YG^#. 2021 Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formation. Stem Cell Reports, 16(5):1290-1301.

主持科研项目

1. 国家自然科学基金委基础科学中心项目(31988101)，2020-2024。

2. 江西省自然科学基金重大项目（20224ACB209001），基于循环肿瘤细胞类器官探究胃癌异质性及转移的机制研究，2022-2026。

科研获奖及专利

科研获奖

曾获教育部长江学者特聘教授、国家杰出青年基金、何梁何利科技进步奖、全国优秀科技工作者、全国创新争先奖等。

专利

1. 陈晔光等，三维培养系统在巴马猪和食蟹猴肠上皮类器官中的应用，专利号：ZL202111298743.8，授权日期：2024-7-19.

2. 陈晔光、方芝等，体液肿瘤类器官培养方法及药敏检测方法，专利号：ZL2023110230314，授权日期：2023-8-15.