NOW: HOME - FACULTY - Research Groups - Miao Guangyan Lab
E-mail：guangyan.miao@ncu.edu.cn
Address：Room 223, Medical Science and Technology Innovation Center
Educational Background
09/2012~07/2017 Peking University Ph.D.
09/2007~07/2012 Peking University B.S.
Professional Experience
01/2026~Present Nanchang University, Institute of Biomedical Innovation, Principal Investigator
12/2020~01/2026 University of Massachusetts Chan Medical School, Postdoctoral Fellow
07/2017~12/2020 Institute of Biophysics, Chinese Academy of Sciences, Assistant Professor, Associate Professor
Awards and Honors
Peking University Outstanding Graduates (Doctoral), Peking University 2017
Peking University Outstanding Doctoral Dissertation, Peking University 2017
Molecular Mechanisms of Autophagy and Its Role in Neurodegenerative Diseases. Autophagy is a lysosome mediated degradation pathway in eukaryotic cells that is essential for maintaining cellular homeostasis. Autophagy dysfunction is closely linked to various human diseases, including aging, metabolic disorders, infectious and immune diseases, cancer, and neurodegenerative diseases. The research group is dedicated to elucidating the molecular mechanisms of autophagy and its functional role in neurodegenerative diseases. The focus is on core pathological processes of neurodegeneration, aiming to uncover the precise molecular mechanisms by which autophagic defects contribute to these diseases, and to develop innovative therapeutic strategies targeting neuroinflammation and pathological microglial activation.
1. Guangyan Miao, Tina M. Fortier, Haibo Liu, Dorothy P. Schafer, Katherine A. Fitzgerald, Junhao Mao, Eric H. Baehrecke. Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration. Nature Structural & Molecular Biology, 2025, 32: 2046–2059.
2. Guangyan Miao, Hongyu Zhao, Yan Li, Mingming Ji, Yong Chen, Yi Shi, Yuhai Bi, Peihui Wang, and Hong Zhang. ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation. Developmental Cell,2021,* 56: 427-442.e5.
3. Guangyan Miao #, Yujie Zhang #, Di Chen, and Hong Zhang. The ER-localized transmembrane protein TMEM39A/SUSR2 regulates autophagy by controlling the trafficking of the PtdIns(4)P phosphatase SAC1. Molecular Cell, 2020, 77: 618-632.e5.
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