NOW: HOME - FACULTY - Research Groups - YU Hua Lab
E-mail：huayu@ncu.edu.cn
Address：Room 219, Medical Science and Technology Innovation Center
Ph.D. in Bioinformatics from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. A total of 26 SCI papers have been published in international journals, three of which were selected as cover articles, and two were featured in multiple renowned media outlets such as Science News. The cumulative citation count of all publications exceeds 2,200, with an H-index of 16. The highest citation count for a first-author paper exceeds 360. Representative research findings were selected for an oral presentation at the International Society for Stem Cell Research (ISSCR) Annual Meeting.
He has long been dedicated to the study of non-coding RNA functions, discovering key non-coding RNAs that drive pluripotent-to-totipotent cell fate transitions, zygotic genome activation, and cancer development, elucidating their regulatory molecular mechanisms, and advancing translational applications. The specific research directions are as follows:
Research Focus 1: Integrate multi-omics data to develop intelligent algorithms and databases for predicting non-coding RNA functions.
Research Focus 2: Identify key non-coding RNAs that regulate pluripotent-to-totipotent cell fate transitions and zygotic genome activation, and investigate their molecular mechanisms of action.
Research Focus 3: Identify key non-coding RNAs that drive the development and progression of malignant tumors, and conduct novel drug development based on these key non-coding RNAs.
Hua Yu#*, Jing Zhao#, Yuxuan Shen, Qiao Lu, Yuheng Liu, Guanglei Xie, Shuhui Chang, Tingying Ge, Nan Li, Ming Chen, Hu Li, Jin Zhang*, Xi Wang*. The dynamic landscape of enhancer-derived RNA during mammalian early embryo development. Cell Reports, 2024, 43(4):114077.
Hua Yu#, Zhen Sun#, Tianyu Tan#, Hongru Pan#, Jing Zhao, Ling Zhang, Jiayu Chen, Yuqing Zhu, Lang Chen, Yuyan Xu, Shaorong Gao, George Q. Daley, Jin Zhang*. rRNA Biogenesis Regulates Mouse 2C-like State by 3D Structure Reorganization of Peri-Nucleolar Heterochromatin. Nature Communications, 2021, 12:6365.
Anhua Lei#, Hua Yu#, Shan Lu, Hengxing Lu, Xizhong Ding, Tianyu Tan, Hailing Zhang, Mengmeng Zhu, Lin Tian, Xudong Wang, Siyu Su, Dixuan Xue, Shaolong Zhang, Wei Zhao, Yuge Chen, Wanrun Xie, Li Zhang, Yuqing Zhu, Jing Zhao, Wenhong Jiang, George Church, Francis Ka-Ming Chan, Zhihua Gao, Jin Zhang*. A second generation M1-polarized CAR macrophage with antitumor efficacy. Nature Immunology, 2023, 25:102-116.
Zhen Sun#, Hua Yu#, Jing Zhao#, Tianyu Tan, Hongru Pan, Bo Gao, Yuqing Zhu, Lang Chen, Cheng Zhang, Li Zhang, Anhua Lei, Yuyan Xu, Xianju Bi, Xin Huang, Cristina Correia, Ming Chen, Qiming Sun, Li Shen, Longfei Wang, Yu Feng, Jianlong Wang, Xiaohua Shen, Hu Li, Hao Wu, George Q. Daley, Jin Zhang*. LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells. Protein & Cell, 2021, 13:490-512.
Jing Zhao#, Ke Yao#, Hua Yu#, Ling Zhang, Yuyan Xu, Lang Chen1, Zhen Sun, Yuqing Zhu, Chen Zhang, Yuli Qian, Zhuyan Ji, Min Zhang, Jie Chen, Cristina Correia, Taylor Weiskittel, Dan Zhang, Hu Li, Wei Xie, Zeping Hu*, Jin Zhang* Metabolic remodelling during early mouse embryo development. Nature Metabolism, 2021, 3:1372-1384
Lin Yang, Yuqing Zhu#, Hua Yu#, Xiaolong Cheng, Sitong Chen, Yulan Chu, He Huang, Jin Zhang*, Wei Li*. scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens. Genome Biology, 2020, 21:19.
Hua Yu#*, Lu Lu#, Bingke Jiao, Chengzhi Liang*. Systematic discovery of novel and valuable plant gene modules by large-scale RNA-seq samples. Bioinformatics, 2019, 35(3):361-364.
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