NOW: HOME - FACULTY - Research Groups - XIONG Jingwei Lab
E-mail：xiongjingwei@ncu.edu.cn
Address：Room 301, Medical Science and Technology Innovation Center
Professor Jingwei Xiong received his B.S. in Biology from Jiangxi University and his Ph.D. from the Institute of Zoology, Chinese Academy of Sciences (CAS). He previously served as an Assistant Professor at Massachusetts General Hospital, Harvard Medical School, and as a Professor at the College of Future Technology, Peking University. In 2023, he joined Nanchang University as a Professor and the Dean of the School of Basic Medical Sciences.
Professor Xiong holds several prominent academic leadership positions. He is currently a member of the General Expert Group for the Ministry of Science and Technology's special project on "Developmental Programming and Metabolic Regulation." Additionally, he serves as a Standing Member of the Webinars Committee of the International Society for Regenerative Biology (ISRB), President of the Cell Signaling Transduction Branch of the Chinese Society for Cell Biology (CSCB), Vice Chair of the Zebrafish Committee of the China Zoological Society, and Associate Editor of the journal Cell Regeneration.
Throughout his career, Professor Xiong has been recognized with numerous prestigious awards, including the NIH K01 Award, the March of Dimes Foundation Award, the Peking University Bayer Investigator Award, and the Peking University Aegon-Industrial Fund Award.
Professor Xiong is primarily engaged in basic and translational research on cardiovascular development and cardiac regeneration. He is credited with discovering the world’s first combination of small chemical molecules capable of promoting mammalian cardiomyocyte regeneration and treating myocardial infarction.
Key Research Directions:
1. Mechanisms of heart regeneration in zebrafish, mice, and rats.
2. Mechanisms of cardiovascular development in zebrafish.
3. CRISPR-based gene editing and molecular diagnostics.
1. #Chang N, #Sun C, Gao L, Zhu D, Xu X, Zhu X, *Xiong JW, and *Xi J (2013). Genome Editing with RNA-guided Cas9 Nuclease in Zebrafish Embryos. Cell Research, 23:465-72.
2. #Han P, #Zhou XH, Chang N, Xiao CL, Yan S, Ren H, Yang XZ, Zhang ML, Wu Q, Tang Y, Diao JP, Zhu X, Zhang CM, Li CY, *Cheng H, and *Xiong JW (2014). Hydrogen Peroxide Primes Heart Regeneration with a Derepression Mechanism. Cell Research, 24: 1091-1107.
3. Xiao CL#, Gao L#, Hou Y, Xu C, Chang N, Wang F, Hu K, He A, Luo, Y, Wang J, Peng JR, Tang F, Zhu X*, and Xiong JW*. (2016). Chromatin Remodeling Factor Brg1 Regulates Myocardial Proliferation and Regeneration in Zebrafish. Nature Communications, 7, 13787.
4. Pang MJ#, Bai L#, Zong W#, Wang X, Bu Y, Xiong C, Zheng J, Li J, Gao W, Feng Z, Chen LY, Zhang J, Cheng H, Zhu X*, and Xiong JW*. (2020). Light-Sheet Fluorescence Imaging Charts the Gastrula Origin of Vascular Endothelial Cells in Early Zebrafish Embryos. Cell Discovery, 6:74. doi: 10.1038/s41421-020-00204-7.
5. Du J#, Zheng L#, Gao P, Yang H, Yang WJ, Guo F, Liang R, Feng M, Wang Z, Zhang Z, Bai L, Bu Y, Xing S, Zheng W, Wang X, Quan L, Hu XL, Wu H, Chen Z, Chen, LY, Wei K, Zhang Z, Zhu X, Zhang XL, Tu Q, Zhao SM*, Lei X*, and Xiong JW*. (2022). A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. Cell Stem Cell, 29:545-558.
6. Zhou X#, Zhang C#, Wu XY#, Hu X, Zhang Y, Wu XL, Zheng L, Gao P, Du JY, Zheng W, Shang H, Hu K, Jiang Z, Nie Y, Hu S, Xiao RP, Zhu X*, and Xiong JW*. (2022). Dusp6 Deficiency Improves Cardiac Repair by Attenuating Neutrophil Activity in the acute inflammatory phase of myocardial infarction. Nature Communications 13(1):6672.
7. Xiao CL#, Hou JJ#, Song YB, Wang F, Zheng JY, Wang J, Luo LF, Wan-Qiu DingC, Zhu X*, and Xiong JW*. (2023). Endothelial Brg1 negatively regulates Notch signaling during zebrafish heart regeneration. bioRxiv 2022.05.18.492445; doi: https://doi.org/10.1101/2022.05.18.492445. npj npj Regenerative Medicine 8(1):21. doi: 10.1038/s41536-023-00293-4.
8. Zhang Z, Chen Y, Zheng L, Du J, Zhu X*, Xiong JW*. (2023). Dusp6 inhibitor BCI improves cardiac repair by fine-tuning macrophage differentiation and inflammation. Disease Models & Mechanisms 16, dmm049662. doi:10.1242/dmm.049662.
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