FACULTY

LI Yehua Lab

LI Yehua

Distinguished Research Fellow, Ph.D. Supervisor

  • E-mail:liyehua@ncu.edu.cn

  • Address:Room 319, Medical Science and Technology Innovation Center

Biography
Research
Group Members
Publications

Education Experience

From September 2008 to June 2012: Bachelor of Science, School of Life Sciences, Tsinghua University;

From August 2012 to June 2018: Doctor of Philosophy, School of Life Sciences, Tsinghua University;

Work Experience

From June 2018 to September 2024: Postdoctoral Fellow, Beijing Institute of Life Sciences;

From September 2024 to Present: Distinguished Research Fellow, Institute of Biomedical Innovation, Nanchang University



Investigating the role and regulatory mechanisms of copper death and copper ion metabolism in major diseases such as tumours by combining organoid research.



1、Li, Yehua*; Ma, Jiahao*; Wang, Rui; Luo, Yuanhanyu; Zheng, Sanduo; Wang, Xiaodong; Zinc transporter 1 functions in copper uptake and cuproptosis, Cell Metabolism2024, 36(9): 2118-2129 (*Co-first authors)

2、Li, Yehua#; Wang, Jiawen; Wang, Rui; Wang, Xiaodong#; Gut bacteria induce IgA expression in pituitary hormone-secreting cells during aging, iScience2023, 26(10):107747 (#Corresponding)

3、Wang, Shan*; Li, Siqi*; Li, Yehua*; Jiang, Quanlong; Li, Xintong; Wang, Yalong; Han, Jing-Dong; Liu, Yuan; Chen, Ye-Guang; Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formationStem Cell Reports2021, 16(5): 1290-1301 (*Co-first authors)

4、Li, Yehua*; Liu, Yuan*; Liu, Bofeng; Wang, Jilian; Wei, Siting; Qi, Zhen; Wang, Shan; Fu, Wei; Chen, Ye-Guang; A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5(+) intestinal stem cell maintenance, Cell Discovery2018, 4(4): 49-49 (*Co-first authors)

5、Qi, Zhen*; Li, Yehua*; Zhao, Bing; Xu, Chi; Liu, Yuan; Li, Haonan; Zhang, Bingjie; Wang, Xinquan; Yang, Xiao; Xie, Wei; Li, Baojie; Han, Jing-Dong Jackie; Chen, Ye-Guang; BMP restricts stemness of intestinal Lgr5(+) stem cells by directly suppressing their signature genes, Nature Communications2017, 8(8): 13824-13824 (*Co-first authors)

6、Wu, Ye*; Li, YeHua*; Li, Xiang*; Zou, Yan; Liao, Hong-Li; Liu, Lei; Chen, Ye-Guang; Bierer, Donald; Hu, Hong-Gang; A novel peptide stapling strategy enables the retention of ring-closing amino acid side chains for the Wnt/beta-catenin signalling pathway, Chemical Science2017,11(8): 7368-7373 (*Co-first authors)

7、Zhao, Bing*; Qi, Zhen*; Li, Yehua*; Wang, Chongkai; Fu, Wei; Chen, Ye-Guang; The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells, Nature Communications2015, 6(7166) (*Co-first authors)