NOW: HOME - FACULTY - Research Groups - WANG Zheng Lan
E-mail：wz1103@ncu.edu.cn
Address：Room 321, Medical Science and Technology Innovation Center
Dr. Wang received his Bachelor’s degree from Tianjin University and his Ph.D. from Nankai University. He subsequently conducted postdoctoral research and was promoted to Associate Research Fellow in the laboratory of Academician Hong Zhang at the Institute of Biophysics, Chinese Academy of Sciences. He joined Nanchang University as a full-time faculty member in January 2024.
I am primarily engaged in research on the molecular mechanisms of autophagy and biomacromolecular phase transition. As the first and/or corresponding author, I have published multiple papers in top-tier international academic journals such as Molecular Cell, Developmental Cell, and JCB. I also lead projects under the National Natural Science Foundation of China's Original Exploration Program and General Program.
研究论文：
1. Zheng Wang*#, Chun Yang*, Dongshi Guan, Jiaqi Li, and Hong Zhang. Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates. Developmental Cell, 2023, 58: 919-932. (Featured article, highlighted in Developmental Cell entitled “Soaping up transcriptional condensates”).
2. Zheng Wang, Di Chen, Dongshi Guan, Xiaobo Liang, Jianfeng Xue, Hongyu Zhao, Guangtao Song, Jizhong Lou, Yan He, and Hong Zhang#. Material properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway. Journal of Cell Biology, 2022, 221: e202112024.
3. Zheng Wang*, Guangyan Miao*, Xue Xue*, Xiangyang Guo, Chongzhen Yuan, Zhaoyu Wang, Gangming Zhang, Yingyu Chen, Du Feng, Junjie Hu, and Hong Zhang#. (2016) The Vici syndrome protein EPG5 is a Rab7 effector that determines the fusion specificity of autophagosomes with late endosomes/lysosomes. Molecular Cell, 2016, 63: 781-795. (Recommended by “Faculty of 1000”).
4. Zheng Wang, Gangming Zhang, and Hong Zhang#. Protocol for analyzing protein liquid–liquid phase separation. Biophysics Reports, 2019, 5: 1-9.
5. Zheng Wang*, Xue Yang*, Shuang Guo, Yin Yang, Xun-Cheng Su, Yuequan Shen#, and Jiafu Long#. Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism. Journal of Biological Chemistry, 2014, 289: 27376-27385.
6. Zheng Wang*, Xue Yang*, Xinlei Chu, Jinxiu Zhang, Hao Zhou, Yuequan Shen#, and Jiafu Long#. (2012) The structural basis for the oligomerization of the N-terminal domain of SATB1. Nucleic Acids Research, 2012, 40: 4193-4202.
特邀综述：
1. Zheng Wang#, Jizhong Lou#, and Hong Zhang#. (2022) Essence determines phenomenon: Assaying the material properties of biological condensates. Journal of Biological Chemistry, 2022, 298:101782.
2. Zheng Wang, and Hong Zhang#. (2019) Phase separation, transition, and autophagic degradation of proteins in development and pathogenesis. Trends in Cell Biology, 2019, 29: 417-427. (Cover story).
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