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E-mail：xiaochenglu@ncu.edu.cn
Address：Room 301, Medical Science and Technology Innovation Center
Dr. Chenglu Xiao received his bachelor's degree from the Science Pilot Program at China Agricultural University and his Ph.D. from Peking University. From November 2019 to December 2023, he served as a Lecturer in the Department of Basic Veterinary Medicine at the College of Veterinary Medicine, China Agricultural University. Since January 2024, he has been working as a Researcher at the Institute of Biomedical Innovation, Nanchang University.
Myocardial infarction poses a serious threat to human life and health. While various clinical treatments can alleviate its symptoms, they are unable to repair dead cardiomyocytes. In contrast, lower vertebrates such as zebrafish and some newborn mammals can regenerate their hearts after injury. Studying the cellular and molecular mechanisms of cardiac regeneration can provide a theoretical basis for repairing cardiac damage in adult organisms. I have long been engaged in research on the cellular and molecular mechanisms of cardiac regeneration and have discovered that molecules such as Brg1 are involved in regulating the proliferation and regeneration of cardiomyocytes.
1.Cheng-Lu Xiao#, Jun-Jie Hou#, Fang Wang, Ya-Bing Song, Ji-Yuan Zheng, Ling-Fei Luo, Jian-Bin Wang, Wan-Qiu Ding*, Xiao-Jun Zhu*, Jing-Wei Xiong*. Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration. NPJ Regenerative Medicine, 2023, 8(1): 21.
2.Meng-Dong Wang#, Di Wang#, Yue Lang, An-Wen Shao, Rui Zhang, Jun Tang, Dong-Ming Lai*, Cheng-Lu Xiao*. L3MBTL3 is induced by HIF-1α and fine tunes the HIF-1α degradation under hypoxia in vitro. Heliyon, 2023, 9(2): e13222.
3.Cheng-Lu Xiao#, Jing-Wei Xiong*. ERK signaling waves via body-wall muscles guide planarian whole-body regeneration across long distances. Cell Regeneration, 2023, 12(1): 36.
4. Cheng-Lu-Xiao#, Fang Wang, Jun-Jie Hou, Xiao-Jun Zhu*, Jing-Wei Xiong*. Nanoparticle-mediated siRNA gene-silencing in adult zebrafish heart. JoVE, 2018, (137): 58054.
5. Cheng-Lu Xiao#, Lu Gao#, Yu Hou, Cong-Fei Xu, Nan-Nan Chang, Fang Wang, Ke-Ping Hu, Ai-Bin He, Ying Luo, Jun Wang, Jin-Rong Peng, Fu-Chou Tang, Xiao-Jun Zhu*, and Jing-Wei Xiong*. Chromatin remodeling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish. Nature Communications, 2016, 7:13787.
6. 王迪#, 高超, 王孟冬, 肖成路*, 唐军*. UHRF1依赖自身的甲基化修饰调控HIF-1α的蛋白水平. 中国细胞生物学学报, 2023, 45(07):1009-1019.
7. 肖成路#*. 再生过程中心肌细胞去分化和增殖的研究进展. 中国细胞生物学学报, 2022, 44(08): 1496-1508.
8. Mei-Jun Pang#, Connie Xiong, Cheng-Lu Xiao, Jian-Yong Du, Li-Xia Zheng, Lin-Lu Bai, Xiao-Jun Zhu*, Jing-Wei Xiong*. Critical role of zebrafish dnajb5 in myocardial proliferation and regeneration. J Genet Genomics, 2020, 47(8):493-496.
9. Xiao-Jun Zhu#, Cheng-Lu Xiao, Jing-Wei Xiong*. Epigenetic regulation of organ regeneration in zebrafish. JCDD, 2018, 5(4):57.
10. Pei-Dong Han#, Xiao-Hai Zhou#, Nan-Nan Chang#, Cheng-Lu Xiao, Shou-Yu Yan, He Ren, Xin-Zhuang Yang, Mei-Ling Zhang, Qing Wu, Bo-Yang Tang, Ju-Peng Diao, Xiao-Jun Zhu, Chuan-Mao Zhang, Chuan-Yun Li, He-Ping Cheng*, Jing-Wei Xiong*. Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Research, 2014, 24(9):1091-107.
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