NOW: HOME - FACULTY - Research Groups - PAN Bingxing Lab
E-mail：panbingxing@ncu.edu.cn
Address：Room 201, Medical Science and Technology Innovation Center
Research in our lab has focused on the fundamental and translational research of major psychiatric disorders, particularly anxiety and depression. We aim to establish a systematic research framework that encompasses the onset, progression, and intervention of major psychiatric disorders, bridging the gap between basic research and clinical application. To achieve this goal, we integrate a variety of advanced methodologies and cutting-edge technologies. Our research incorporates animal behavior analysis, neural circuit tracing, in vivo calcium imaging, optogenetics, chemogenetics, electrophysiology, and comprehensive multi-omics analyses alongside clinical sample investigations. This multidisciplinary approach allows us to systematically explore the multi-dimensional pathogenesis of psychiatric disorders at molecular, cellular, neural circuit, and behavioral levels. Through cross-scale integrative research spanning molecular, circuitry, behavioral, and clinical dimensions, we are dedicated to identifying clinically translatable diagnostic biomarkers and develop novel intervention strategies based on newly uncovered mechanisms. Our work provides theoretical and technological support for the precise diagnosis and treatment of psychiatric disorders.
Research Areas:
· Investigation of neural circuit and molecular mechanisms underlying emotion and psychiatric disorders, such as anxiety and depression.
· Development and validation of clinically relevant biomarkers for anxiety disorders, depression, and related psychiatric conditions.
· Research on novel mechanism-based pharmacological and non-pharmacological intervention strategies for psychiatric disorders.
1. Ren-Wen Han*, Zi-Yi Zhang, Chen Jiao, Ze-Yu Hu, Bing-Xing Pan*.Synergism between two BLA-to-BNST pathways for appropriate expression of anxiety-like behaviors in male mice. Nature Communications, 2024, 15: 3455.
2. Wen-Hua Zhang, Jun-Yu Zhang, Andrew Holmes, Bing-Xing Pan*. Amygdala circuit substrates for stress adaptation and adversity. Biological Psychiatry, 2021, 89: 847-856.
3. Wei-Zhu Liu#, Wen-Hua Zhang#, Zhi-Heng Zheng, Jia-Xin Zou, Xiao-Xuan Liu, Shou-He Huang, Wen-Jie You, Ye He, Jun-Yu Zhang, Xiao-Dong Wang, Bing-Xing Pan*. Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety. Nature Communications, 2020, 11: 2221.
4. Wen-Hua Zhang, Wei-Zhu Liu, Ye He, Wen-Jie You, Jun-Yu Zhang, Hong Xu, Xiao-Li Tian, Bao-Ming Li, Lin Mei, Andrew Holmes, Bing-Xing Pan*. Chronic stress causes projection-specific adaptation of amygdala neurons via small-conductance calcium-activated potassium channel downregulation. Biological Psychiatry, 2019, 85: 812-828.
5. Jun-Yu Zhang#, Tao-Hui Liu#, Ye He, Han-Qing Pan, Wen-Hua Zhang, Xiao-Li Tian, Xiao-Ping Yin, Bao-Ming Li, Xiao-Dong Wang, Andrew Holmes, Ti-Fei Yuan, Bing-Xing Pan*. Chronic stress remodels synapses in an amygdala circuit-specific manner. Biological Psychiatry, 2019, 85: 189-201.
校内链接
校外链接
Address: No. 1299 Xuefu Avenue, Honggutan District, Nanchang City, Jiangxi Province
Tel：+86-0791-83968485
E-mail：ibi@ncu.edu.cn
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