NOW: HOME - FACULTY - Research Groups - XU Shimeng Lab
E-mail：shimeng.xu@ncu.edu.cn
Address：Room 427, Medical Science and Technology Innovation Center
Dr. Shimeng Xu focuses on cholesterol metabolism and lipid droplet biology. He has established a research framework that progresses from the discovery of novel pathways and elucidation of their functions to the screening of small molecules and the development of targeted therapeutics.
Educational Experience
[1] 200609-201007 Guizhou University Undergraduate Degree
[2] 201009-201607 Institute of Biophysics, Chinese Academy of Sciences Doctoral Degree
Work Experience
[1] 201607-201801 Institute of Biophysics, Chinese Academy of Sciences, Postdoctoral Researcher
[2] 201801-202206 UTSouthwestern Medical Center, Postdoctoral Researcher
[3] 202207-202504 UTSouthwestern Medical Center, Senior Research Scientist
[4] 202504-Now Nanchang University, PI for Lipid Metabolism and Related Diseases
1. Discovery and Mechanistic Study of Novel Cholesterol Synthesis and Metabolic Pathways;
2. Screening and Target Validation of Small-Molecule Modulators of Cholesterol Synthesis and Metabolism;
3. Exploration of Novel Therapeutic Targets and Drug Screening for Metabolic Dysfunction Associated Steatotic Liver Disease.
(1) Shimeng Xu*; Jared C. Smothers; Daphne Rye; Shreya Endapally; Hong Chen; Shili Li; Guosheng Liang; Maia Kinnebrew; Rajat Rohatgi; Bruce A. Posner; Arun Radhakrishnan; A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells, PNAS, 2024, 121(7)
(2) Shimeng Xu*; Linda Donnelly; Daniel L. Kober; Myra Mak; Arun Radhakrishnan; Development of a monoclonal antibody to study MARCH6, an E3 ligase that regulates proteins that control lipid homeostasis, Journal of Lipid Research, 2024, 65(11): 100650
(3) Daniel L. Kober*; Shimeng Xu*; Shili Li; Bilkish Bajaj; Guosheng Liang; Daniel M. Rosenbaum; Arun Radhakrishnan ; Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis, PNAS, 2020, 11
(4) Yaqin Deng; Chang Zhou; Ahmed Hammad Mirza; Adekunle Toyin Bamigbade; Shuyan Zhang; Shimeng Xu#; Pingsheng Liu#; Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics, BBA- Mol Biol, 2021, 1866(7)
(5) Ting Huang*; Adekunle T. Bamigbade*; Shimeng Xu*; Yaqin Deng; Kang Xie; Ololade O. Ogunsade; Ahmed Hammad Mirza; Jifeng Wang; Pingsheng Liu; Shuyan Zhang ; Identification of noncoding RNAencoded proteins on lipid droplets, Science Bulletin, 2021, 66(4): 314-318
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