FACULTY

LEI Yang Lab

LEI Yang

Distinguished Research Fellow, Ph.D. Supervisor

  • E-mail:leiyang2016@qq.com

  • Address:Room 305, Medical Science and Technology Innovation Center

Biography
Research
Group Members
Publications

Professional Experience

1. 2024.07-Present Nanchang University

2. 2016.03-2024.06 National Engineering Research Center for Biomaterials, Sichuan University

3. 2014.08-2016.02 Harvard Medical School, USA

Educational Background

1. 2010.08-2014.08 Doctoral Candidate, Clemson University

2. 2008.09-2010.06 Master Candidate, Beihang University (BUAA)

3. 2004.09-2008.06 Undergraduate, Nanjing University of Aeronautics and Astronautics (NUAA)

Academic Affiliations

1. Young Editorial Board Member, Journal of Leather Science and Engineering, 2022–Present

2. Young Editorial Board Member, Cardiology Plus, 2025–Present

3. Invited Reviewer for journals including Advanced Science, Acta Biomaterialia, Advanced Healthcare Materials, Journal of Materials Chemistry B, Frontiers in Bioengineering and Biotechnology, and Journal of Leather Science and Engineering; Core Member, Innovation Unit for Minimally Invasive Treatment of Structural Heart Disease, Chinese Academy of Medical Sciences, 2021–2025

4. Expert, National Expert Database for Postgraduate Education Evaluation and Monitoring, 2022–Present

5. Expert, Expert Database of the National Science and Technology Management Information System, Ministry of Science and Technology, 2017–Present

6. Core Member, Innovative Research Team of Cardiovascular Materials and Devices (Team with Engineering Characteristics), Sichuan University, 2021–2025

Honors & Awards

1. First Class Award of Technological Invention in the Outstanding Scientific Research Achievements of Institutions of Higher Education (Project Title: Key Materials and Technologies for Minimally Invasive Interventional Self-Expandable Pulmonary Valve System; Ranked 3rd among 6 contributors), Ministry of Education of the People's Republic of China, 2021

2. Young Scientist Award at the Annual Conference of the Chinese Society for Biomaterials & Korean Society for Biomaterials, Chinese Society for Biomaterials (CSBM) & Korean Society for Biomaterials (KSB), 2020

3. National Special Prize in the 17th “Challenge Cup” National College Students’ Extracurricular Academic Science and Technology Works Competition; Affiliation: Sichuan University; Entry Title: “Heart Valve Innovation” -- A Pre-loadable Artificial Aortic Valve Based on Free Radical Polymerization Cross-Linking; Supervisors: Wang Yunbing, Guo Gaoyang, Lei Yang, 2022

4. Gold Award of the 6th Sichuan International “Internet Plus” College Students Innovation and Entrepreneurship Competition; Affiliation: Sichuan University; Entry Title: Heart Phase Valve, the world’s first pre-installed interventional heart valve; Supervisors: Lei Yang, Guo Gaoyang, 2020

Other

Research Interests & Fields

1. Artificial biological heart valve leaflet materials (Crosslinking principles and novel methods for leaflet materials; functional monomer-polymerized crosslinked biological leaflet materials; anti-calcification and anti-coagulation technologies and mechanisms; novel dry-state leaflet materials; novel low-immunogenicity biological valve materials; synthetic polymer-based leaflet materials)

2. Human amniotic membrane medical materials (Dry preservation; novel crosslinking methods for amniotic membrane; injectable amniotic membrane powder for osteoarthritis treatment)

3. Medical adhesives (Medical solid pressure-sensitive adhesives; medical powder adhesives)

4. Collagen-Based medical materials (Application research of animal-derived collagen raw materials in medical materials and cosmetics fields)

5. Ophthalmic medical materials (Sutureless human-derived biological amniotic membrane; ocular surface lubricants; ophthalmic gels; glaucoma microstents)

6. Injectable fluid gels and microspheres (For intra-articular injection in osteoarthritis treatment)

7. Antibody conjugation and cell purification kits (Antibody conjugation kits for serum and vaccine purification; cell purification kits for cell therapy applications)

Patents

35 authorized invention patents, including 7 as the first inventor. Selected patents are listed below:

1. A Crosslinking Treatment Method for Improving Elastin Stability of Biological Valves (Patent No.: 201811128254.6)

2. A Dry Artificial Biological Heart Valve Containing Endothelialization-Promoting Peptides and Its Preparation Method (Patent No.: 201910408742.0)

3. A Method for Promoting Endothelialization of Biological Heart Valves (Patent No.: 201811201583.9)

4. An Endothelialized Biological Heart Valve and Its Preparation Method (Patent No.: 202010040644.9)

5. A Non-Glutaraldehyde Preloadable Dry Biological Valve Material and Its Preparation Method (Patent No.: 202010097281.2)



Research Directions:

  1. Cardiovascular biomedical materials and devices, including materials for artificial biological heart valve leaflets;

  2. Collagen-based medical materials;

  3. Medical adhesives;

  4. Ophthalmological medical materials.



1. Kailei Ding, Cheng Zheng, Xueyu Huang, Li Yang, Yang Lei*, Yunbing Wang*. A bioprosthetic heart valve material prepared by copolymerization of 2-Amino-4-pentanoic acid modified pericardium and N, N-Dimethylacrylamide. Composites Part B: Engineering. 2022, 243, 110120.

2. Cheng Zheng, Kailei Ding, Xueyu Huang, Li Yang, Yang Lei* and Yunbing Wang. A bioprosthetic heart valve prepared by copolymerization of 2-isocyanatoethyl methacrylate modified pericardium and functional monomer. Composites Part B: Engineering. 2022, 238, 109922.

3. Shumang Zhang, Cheng Zheng, Meiling Li, Kailei Ding, Xueyu Huang, Xuyue Liang, Yang Lei*, Qing Jiang*, Yunbing Wang*. Sodium lignosulfonate cross-linked bioprosthetic heart valve materials for enhanced cytocompatibility, improved hemocompatibility, and reduced calcification. Composites Part B: Engineering. 2022, 234, 109669.

4. Yang Lei, Nasim Nosoudi, and Naren Vyavahare*. Targeted chelation therapy with EDTA-loaded albumin nanoparticles regresses arterial calcification without causing systemic side effects. Journal of Controlled Release. 2014, 196:79-86.

5. Gaoyang Guo, Linhe Jin, Binggang Wu, Haiyang He, Fan Yang, Liangpeng Xu, Yang Lei*, Yunbing Wang*. A method for simultaneously crosslinking and functionalizing extracellular matrix-based biomaterials as bioprosthetic heart valves with enhanced endothelialization and reduced inflammation. Acta Biomaterialia. 2021, 119, 89-100.

6. Gaoyang Guo, Linhe Jin, Wanyu jin, Liang Chen, Yang Lei*, Yunbing Wang*. Radical polymerization-crosslinking method for improving extracellular matrix stability in bioprosthetic heart valves with reduced potential for calcification and inflammatory response. Acta Biomaterialia. 2018, 82:44-55.

7. Li Yang, Shuang Xie, Kailei Ding, Yang Lei*, and Yunbing Wang. The study of dry biological valve crosslinked with a combination of carbodiimide and polyphenol. Regenerative Biomaterials. 2021, 8(1): rbaa049. DOI: 10.1093/rb/rbaa049.

8. Yang Lei#, Xiaorong Lan#, Zhoukun He*, Anlin Yin, Wanyu Jin, Qinsheng Hu, Yunbing Wang*. Multifarious anti-biofouling bioprosthetic heart valve materials with the formation of interpenetrating polymer network structures. Materials & Design. 2021, 206, 109803.

9. Xiaorong Lan#, Yang Lei#, Zhoukun He*, Anlin Yin, Linhua Li, Zhonglan Tang, Meiling Li, Yunbing Wang*. A transparent hydrophilic anti-biofouling coating for intraocular lens materials prepared by "bridging" of the intermediate adhesive layer. Journal of Materials Chemistry B. 2021, 9, 3696-3704.

10. Binggang Wu#, Cheng Zheng#, Kailei Ding, Xueyu Huang, Meiling Li, Shumang Zhang, Yang Lei*, Yingqiang Guo, Yunbing Wang*. Cross-Linking Porcine Pericardium by 3,4-Dihydroxybenzaldehyde: A Novel Method to Improve the Biocompatibility of Bioprosthetic Valve. Biomacromolecules. 2021, 22(2):823-836.