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GONG Xin Lab

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GONG Xin

Distinguished Research Fellow, Ph.D. Supervisor

  • E-mail：gongx@ncu.edu.cn

  • Address：

Biography
Research
Group Members
Publications

Education

2006–2010, Huazhong University of Science and Technology, School of Life Science and Technology, Undergraduate

2010–2015, Tsinghua University, School of Life Sciences, Ph.D.

Work Experience

2015.07–2017.07, Tsinghua University, School of Basic Medical Sciences, Postdoctoral Fellow

2017.08–2018.12, Princeton University, Department of Molecular Biology, Postdoctoral Fellow

2018.12–2026.01, Southern University of Science and Technology, School of Life Sciences, Principal Investigator (PI), Doctoral Supervisor, Research Professor, Associate Professor

2026.02–present, Nanchang University, Institute of Biomedical Innovation / School of Basic Medical Sciences / The Second Affiliated Hospital, Professor



The Gong laboratory focuses on structural biology and drug target discovery. The team systematically investigates the structure and function of key proteins involved in lipid metabolism, aiming to elucidate the molecular mechanisms underlying lipid homeostasis. Based on structural insights, they explore targeted intervention strategies for related diseases. In parallel, the lab also studies the structural mechanisms of other important drug target proteins to facilitate the development of novel therapeutics.



1. Ma X*, Wang W*, Zhang J*, Jiang Z*, Xu C*, Zhu W, Shi B, Yang W, Su H, Wang X, Chen D, Wang Y, Wang J, Wang J, Liu X, Wang X, Huang X, Xie W, Cai Y, Xu K, Xin P, Liu L, Lü P, Wang Y, Chu J, Gong X#, Chu C#, Hu B#. NRT1.1B acts as an abscisic acid receptor in integrating compound environmental cues for plants. Cell. 2025 Aug 7:S0092-8674(25)00816-5.

2. Wu X*, Gong X#, Xie T#. Mechanisms of aureobasidin A inhibition and drug resistance in a fungal IPC synthase complex. Nature Communications. 2025 May 30;16(1):5010.

3. Zhang Z*, Fang Q*, Xie T#, Gong X#. Mechanism of ceramide synthase inhibition by fumonisin B1. Structure. 2024 Sep 5; 32, 1-10.

4. Xie T*, Dong F*, Han G*, Wu X*, Liu P, Zhang Z, Zhong J, Niranjanakumari S, Gable K, Gupta SD, Liu W, Harrison PJ, Campopiano DJ, Dunn TM#, Gong X#. Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide. Cell Reports. 2024 Feb 27;43(2),113717.

5. Xie T*, Fang Q*, Zhang Z, Wang Y, Dong F, Gong X#. Structure and mechanism of a eukaryotic ceramide synthase complex. The EMBO Journal. 2023 Dec 11;42(24):e114889.

6. Xie T*, Liu P*, Wu X, Yue J, Dong F, Zhang Z, Mahawar U, Farooq F, Vohra H, Fang Q, Liu W, Wattenberg BW#, Gong X#. Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nature Communications. 2023 Jun 13;14(1):3475.

7. Liu P*, Xie T*, Wu X, Han G, Gupta SD, Zhang Z, Yue J, Dong F, Gable K, Niranjanakumari S, Li W, Wang L, Liu W, Yao R, Cahoon EB, Dunn TM, Gong X#. Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex. Science Advances. 2023 Mar 29;9(13):eadg0728.

8. Xie T*, Zhang Z*, Yue J*, Fang Q, Gong X#. Cryo-EM structures of the human surfactant lipid transporter ABCA3. Science Advances. 2022 Apr 8;8(14): eabn3727.

9. Li W*, Wang L*, Wierbowski BM*, Lu M, Dong F, Liu W, Li S, Wang P, Salic A#, Gong X#. Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Nature Communications. 2021 Nov 29;12(1):6966.

10. Xie T*, Zhang Z*, Fang Q, Du B, Gong X#. Structural basis of substrate recognition and translocation by human ABCA4. Nature Communications. 2021 Jun 22;12(1):3853.

11. Li S*, Xie T*, Liu P*, Wang L, Gong X#. Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex. Nature Structural & Molecular Biology. 2021 Mar;28(3):249-257.

12. Ma L*, Guan Z, Wang Q, Yan X, Wang J, Wang J, Cao J, Zhang D, Gong X#, Yin P#. Structural insights into the photoactivation of Arabidopsis CRY2. Nature Plants. 2020 Nov 16;6(12):1432-1438.

13. Qian H*, Cao P*, Hu M, Gao S, Yan N#, Gong X#. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nature Communications. 2019 May 24;10(1):2320.

14. Qian H*, Zhao X, Cao P, Lei J, Yan N#, Gong X*,#. Structure of the human lipid exporter ABCA1. Cell. 2017 Jun 15;169(7):1228–1239.

15. Gong X*, Qian H*, Cao P*, Zhao X, Zhou Q, Lei J, Yan N#. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018 Aug 10;361(6402).

16. Gong X*, Qian H*, Shao W*, Li J, Wu J, Liu J, Li W, Wang H, Espenshade PJ#, Yan N#. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Research. 2016 Nov;26(11):1197-1211.

17. Gong X*, Qian H*, Zhou X*, Wu J*, Wan T*, Cao P, Huang W, Zhao X, Wang X, Wang P, Shi Y, Gao GF, Zhou Q#, Yan N#. Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell. 2016 Jun 2;165(6):1467-78.

18. Gong X*, Li J*, Shao W*, Wu J, Qian H, Ren R, Espenshade PJ#, Yan N#. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Research. 2015 Apr;25(4):401-11.


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