NOW: HOME - FACULTY - Research Groups - WANG Duo Lab
E-mail：wangduo@ncu.edu.cn
Address：Room 525, Medical Science and Technology Innovation Center
Education
2008.09–2013.06, B.M. in Medical Laboratory Science, Shandong First Medical University.
2013.09–2018.10, Ph.D. in Biomedical Engineering, Tongji University.
Academic Experience
2019.01–2023.12 Postdoctoral Research Fellow, Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California.
2024.01–2025.06 Research Associate, Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California.
2025.06–2026.08 Postdoctoral Research Fellow, University of Michigan Medical School.
Awards and Honors
Outstanding Graduate of Shandong Province, Shandong First Medical Universit, 2013
Outstanding Student, Tongji University, 2014
Guanghua Scholarship, Tongji University, 2017
Other Patents
1. Universal medium for mammalian pluripotent stem cells and applications thereof for human/ mouse/rat. U.S. patent, application No. 63/798,735.
2. Methods and compositions for generating bovine naive embryonic stem cells. U.S. patent, application No. 63/798,645.
3. Germline-competent rabbit embryonic stem cells. U.S. patent, application No. 63/748,241.
4. Culture medium and method for the directed differentiation of rat embryonic stem cells into cardiomyocytes. Chinese patent, No. CN108531449B.
5. One-step method for constructing multigene modification vectors for eukaryotic cells. Chinese Patent, No. CN104531749B.
6. An auxiliary device for exosome injection. Chinese Patent, Application No. CN202511967591.4.
7. A self-assembled nanocomposite material and its preparation method and applications. Chinese Patent, Application No. 202610152691.X.
Our laboratory investigates the molecular mechanisms regulating embryonic stem cell self-renewal and cell fate determination. We seek to define the conserved and species-specific principles underlying embryonic stem cell self-renewal, establish culture conditions for the derivation and long-term maintenance of authentic embryonic stem cells from non-rodent mammals, and translate newly identified regulatory targets into improved culture strategies for adult stem cells and applications in regenerative medicine. Building on this work, we develop stem cell-derived organoid models and generate genetically engineered rabbit models of human diseases using rabbit embryonic stem cells, thereby enabling us to elucidate the molecular mechanisms underlying embryonic development and disease pathogenesis, identify potential strategies for tissue regeneration and disease treatment, and facilitate the translation of fundamental discoveries into biomedical applications.
1. Wang D(co-corresponding)*, Ming H, Yang D, Cui X, Freeman Z, Tsai LK, Wei Z, Liu L, Scatolin GN, Bennett B, Wang X, Yau K, Tao L, Tong X, Wang S, Shi KX, Evseenko D, Van Handel B, Guo L, Dai X, Xiong Y, Zhang B, Wang Y, Iyyappan R, Ojeda-Rojas OA, Hu G, McGinnis L, Paulson R, McKim D, Kong X, Xia X, Zhang J, Chen YE, Jiang Z*, Xu J*, Ying QL*. A universal 6iL/E4 culture system for deriving and maintaining embryonic stem cells across mammalian species. Cell Research, 2026; 36: 611-28.
2. Wang D(co-corresponding)*#, Wang X#, Malki S, Chan Y, Bennett B, Feng J, Tang J, Chen X, McKim D, Zhang C, Tao L, Xu J, Chen YE, Hu G*, Ying QL*. GSK3α functions as a stemness checkpoint across multiple stem cell states. Cell Research, 2026; 36: 633-36.
3. Wang D(co-corresponding)*#, Chen X*#, Feng J, Jing XA, Tang J, Chadarevian JP, Park H, Lee M, Feng F, Zhang C, Ying QL*. GSK3α negatively regulates GSK3β by decreasing its protein levels and enzymatic activity in mouse embryonic stem cells. Stem Cell Reports, 2025; 20: 102512.
4. Wang D, Liu C, Liu H, Meng Y, Lin F, Gu Y, Wang H, Shang M, Tong C, Sachinidis A, Ying Q, Li L, Peng L. ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling. Stem Cells, 2021; 39: 443-57.
校内链接
校外链接
Address: No. 1299 Xuefu Avenue, Honggutan District, Nanchang City, Jiangxi Province
Tel：+86-0791-83968485
E-mail：ibi@ncu.edu.cn
WeChat Official Account
Copyright ©INSTITUTE OF BIOMEDICAL INNOVATION, NANCHANG UNIVERSITY
NANCHANG UNIVERSITY
